Efficacy and safety of switching to latanoprost 0.005%-timolol maleate 0.5% fixed-combination eyedrops from an unfixed combination for 36 months.

Purpose: We prospectively investigated the intraocular pressure (IOP)-reducing effect, the visual field-maintenance effect, and the adverse reactions caused by administration of latanoprost/timolol maleate fixed-combination eyedrops for 3 years.

Subjects And Methods: The subjects were 162 patients (162 eyes) with glaucoma or ocular hypotension who were using latanoprost and timolol maleate eyedrops concomitantly. The latanoprost and timolol maleate eyedrop regimen was discontinued without any washout period and subsequently changed to a latanoprost-timolol maleate fixed-combination eyedrop regimen.

Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy.

Background: The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety of latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.

Assessment of ocular hypotensive effect and safety 12 months after changing from an unfixed combination to a latanoprost 0.005% + timolol maleate 0.5% fixed combination.

Background: Latanoprost 0.005% + timolol maleate 0.5% combined eyedrops were recently made available in Japan.

Ocular hypotensive effect and safety of travoprost 0.004%/timolol maleate 0.5% fixed combination after change of treatment regimen from β-blockers and prostaglandin analogs.

Introduction: Travoprost 0.004%/timolol maleate 0.5% fixed combination eye drops are available in Japan.

Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension.

Purpose: To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes to adverse reactions via a questionnaire.

Methods: Fifty-two Japanese patients with glaucoma or ocular hypertension were enrolled.

Ocular hypotensive effects and safety over 3 months of switching from an unfixed combination to latanoprost 0.005%/timolol maleate 0.5% fixed combination.

Purpose: Latanoprost 0.005%/timolol maleate 0.5% combination eye drops are now available in Japan.

Quantitative measurement of ocular dominance using binocular rivalry induced by retinometers.

Purpose: To develop a new method using binocular rivalry and retinometers to quantitatively examine ocular dominance and to investigate the magnitude of ocular dominance in cataract patients preoperatively and postoperatively.

Setting: Eye Clinic, Kitasato University School of Medicine Hospital, Sagamihara, Kanagawa, Japan.

Methods: The duration of exclusive visibility of the dominant and nondominant eye target in binocular rivalry were measured in 60 healthy volunteers (study 1) and preoperatively and postoperatively in 10 cataract patients (study 2).