Publications by authors named "Risa Ikuta"
Drug Discov Ther
January 2024
Article Synopsis
- Olaparib is a drug used for treating ovarian cancer, specifically as maintenance therapy after chemotherapy, but it can cause anemia in some patients due to its varying effects on drug concentration in the body.
- A new assay using high-performance liquid chromatography with ultraviolet light (HPLC-UV) has been developed to monitor olaparib concentrations in patients, ensuring effective drug dosage and safety.
- The HPLC-UV method demonstrated high accuracy and reliability, making it a promising tool for clinical use in managing olaparib therapy for ovarian cancer patients.
Article Synopsis
- * The study developed a high-performance liquid chromatography-ultraviolet (HPLC-UV) method to accurately measure cabozantinib concentration in human plasma, achieving a linear calibration curve and high recovery rates.
- * This HPLC-UV method is efficient (9 minutes per measurement) and simple enough to be used in clinical settings for effective patient monitoring.
