Publications by authors named "Riqian Liu"
Photoreceptors are specialized neurons at the core of the retina's functionality, with optical accessibility and exceptional sensitivity to systemic metabolic stresses. Here we show the ability of risk-free, in vivo photoreceptor assessment as a window into systemic health and identify shared metabolic underpinnings of photoreceptor degeneration and multisystem health outcomes. A thinner photoreceptor layer thickness is significantly associated with an increased risk of future mortality and 13 multisystem diseases, while systematic analyses of circulating metabolomics enable the identification of 109 photoreceptor-related metabolites, which in turn elevate or reduce the risk of these health outcomes.
View Article and Find Full Text PDFBackground/aims: To identify the metabolic underpinnings of retinal aging and examine how it is related to mortality and morbidity of common diseases.
Methods: The retinal age gap has been established as essential aging indicator for mortality and systemic health. We applied neural network to train the retinal age gap among the participants in UK Biobank and used nuclear magnetic resonance (NMR) to profile plasma metabolites.
Purpose: This prospective cohort study investigated the longitudinal relationship between hypertension (HTN), defined by the 2017 ACC/AHA guidelines, and changes in choroidal thickness (CT) in patients with type 2 diabetes.
Methods: Patients aged 30-80 years from the Guangzhou Diabetic Eye Study were categorized into non-HTN, stage 1-HTN, and stage 2-HTN groups based on BP criteria. Macular and parapapillary CT were measured using swept-source optical coherence tomography (SS-OCT).
Article Synopsis
- The study aimed to analyze changes in choroidal thickness (CT) and ganglion cell-inner plexiform layer thickness (GC-IPLT) in different types of type 2 diabetes mellitus (T2DM) patients over a 4-year period.
- It categorized patients into five groups based on their β-cell function and insulin resistance, measuring CT and GC-IPLT at the start and after four years using advanced imaging techniques.
- Results showed significant thinning of both CT and GC-IPLT in all groups, with SIDD patients experiencing the fastest decline in CT and SIRD showing the greatest loss in GC-IPLT, indicating microvascular damage and early retinal degeneration linked to these diabetes phenotypes.
Long-Term Prediction and Risk Factors for Incident Visual Field Defect in Nonpathologic High Myopia.
Invest Ophthalmol Vis Sci
August 2024
Purpose: To investigate the long-term patterns and risk factors of visual field defect (VFD) development in nonpathologic high myopia (HM) over an 8-year follow-up.
Methods: This was an observational cohort study. The VFD classification adhered to the Glaucoma Suspects with High Myopia Study Group.
Purpose: To identify longitudinal metabolomic fingerprints of diabetic retinopathy (DR) and to evaluate their usefulness in predicting DR development and progression.
Design: Multicenter, multiethnic cohort study.
Participants: This study included 17 675 participants from the UK Biobank (UKB) who had baseline prediabetes or diabetes, identified in accordance with the 2021 American Diabetes Association guidelines, and were free of baseline DR and an additional 638 participants with type 2 diabetes mellitus from the Guangzhou Diabetic Eye Study (GDES) for external validation.
Article Synopsis
- The study aimed to create and test a prediction model for myopic macular degeneration (MMD) progression in patients with high myopia, utilizing data from a large cohort of participants.
- Researchers analyzed various clinical factors and employed machine learning algorithms, specifically finding that the eXtreme Gradient Boosting algorithm provided the most effective predictions.
- Results indicated that key predictors for MMD progression included factors like age, gender, and ocular measurements, and the model showed promise for identifying patients at risk of vision loss over the next decade.
Purpose: The purpose is to investigate the association between handgrip strength (HGS) and the risk of future diabetic complications in multicountry cohorts.
Methods: The association between HGS and diabetic complications was evaluated using cox models among 84 453 patients with pre-diabetes and diabetes from the UK Biobank with a 12-year follow-up. The association between HGS and longitudinal microcirculatory damage rates was assessed among 819 patients with diabetes from the Guangzhou Diabetic Eye Study (GDES) with a 3-year follow-up.
Frailty and risk of microvascular disease in adults with prediabetes.
Diabetes Metab Syndr
January 2024
Background And Aims: To assess the relationship between frailty phenotypes and the risk of MVD among prediabetics in two prospective cohorts.
Methods: The study included 66,068 and 226 participants with prediabetes from the UK Biobank (UKB) and Chinese Ocular Imaging Project (COIP) in Guangzhou, China, respectively. Frailty was evaluated using the Fried phenotype, which includes weight loss, fatigue, low grip strength, low physical activity, and slow walking pace.
Introduction: The seed weight of soybean [ (L.) Merr.] is one of the major traits that determine soybean yield and is closely related to seed size.
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