Nurse-Led Virtual Delivery of PIECES in Canadian Long-Term Care Homes to Support the Care of Older Adults Experiencing Responsive Behaviors During COVID-19: Qualitative Descriptive Study.

Background: Worldwide, the COVID-19 pandemic has resulted in profound loss of life among older adults living in long-term care (LTC) homes. As a pandemic response, LTC homes enforced infection control processes, including isolating older adults in their rooms, canceling therapeutic programs, and restricting family member visits. Social isolation negatively impacts older adults in LTC, which may result in increased rates of anxiety, depression, physical and cognitive decline, disorientation, fear, apathy, and premature death.

Video Conferencing With Residents and Families for Care Planning During COVID-19: Experiences in Canadian Long-Term Care.

Background And Objectives: Government-mandated health and safety restrictions to mitigate the effects of coronavirus disease 2019 (COVID-19) intensified challenges in caring for older adults in long-term care (LTC) without family/care partners. This article describes the experiences of a multidisciplinary research team in implementing an evidence-based intervention for family-centered, team-based, virtual care planning-PIECESTM approach-into clinical practice. We highlight challenges and considerations for implementation science to support care practices for older adults in LTC, their families, and the workforce.

Spiritually incorporating couple therapy in practice: Christian-accommodated couple therapy as an illustration.

Spiritually incorporating couple therapy (SICT)-couple therapy that incorporates spiritual interventions-has a growing research base. Information is limited on how spiritual interventions are used in practice; thus we studied treatment-as-usual (TAU). SICT is treatment that, at a couple's request, sometimes draws upon spiritual resources when addressing relational issues.

Dysregulation of immune cell and cytokine signalling correlates with clinical outcomes in myelodysplastic syndrome (MDS).

Objectives: Myelodysplastic syndromes (MDS) are characterised by ineffective haematopoiesis. Although hypomethylating agents (HMA) have improved survival in higher-risk MDS, most patients eventually succumb to progressive disease. Utilising samples collected prospectively from three MDS clinical trials, we analysed genetic and immunological biomarkers and correlated them with clinical outcomes.

Factors Contributing to Posttraumatic Growth Following Bereavement.

Multiple factors have been studied to determine their relationship to posttraumatic growth, with findings suggesting the importance of resiliency (Bensimon, 2012), social support (Tedeschi & Calhoun, 2004), event centrality (Taku et al., 2014), religious coping (Pargament et al., 2006), relationship to the deceased (Oginska-Bulik, 2015), and the circumstance of passing (Feigelman et al.

Dynamics of Spontaneous Black Hole Scalarization and Mergers in Einstein-Scalar-Gauss-Bonnet Gravity.

We study the dynamics of black holes in scalar Einstein-Gauss-Bonnet theories that exhibit spontaneous black hole scalarization using recently introduced methods for solving the full, nonperturbative equations of motion. For one sign of the coupling parameter, nonspinning vacuum black holes are unstable to developing scalar hair, while for the other, instability only sets in for black holes with sufficiently large spin. We study scalarization in both cases, demonstrating that there is a range of parameter space where the theory maintains hyperbolic evolution and for which the instability saturates in a scalarized black hole that is stable without symmetry assumptions.

Competing risks analysis of the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer.

Aim: Despite numerous reports over three decades, the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer remains controversial. This cohort study used competing risks statistical methods to examine the association between transfusion and recurrence and colorectal cancer-specific death after potentially curative and noncurative resection.

Method: A hospital database provided prospectively recorded clinical, operative and follow-up information.

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy.

Natural killer (NKs) cells provide rapid responses to viral-infected and malignant cells, including acute myeloid leukemia (AML) blasts. The balance among inhibitory and activating signals, delivered by multiple interactions between ligands on target cells and NK receptors, determines the posture of the NK cell response to either one of target cell elimination or tolerance. The aim of this work was to study the influence of the differential expression of activating and inhibitory NK receptor ligands (NKRLs) by leukemic blasts on clinical outcome in newly diagnosed AML patients.

Variability in the Treatment of Prehospital Hypoglycemia: A Structured Review of EMS Protocols in the United States.

Background: In many industries, limiting variability in process has been associated with a reduction in errors. Hypoglycemia is a common prehospital diabetic emergency for which most EMS systems have a treatment protocol.

Objective: To examine the treatment variability for prehospital hypoglycemia within EMS protocols in the U.

Forgiveness-reconciliation and communication-conflict-resolution interventions versus retested controls in early married couples.

The first 6 months of marriage are optimal for marriage enrichment interventions. The Hope-Focused Approach to couple enrichment was presented as two 9-hr interventions--(a) Handling Our Problems Effectively (HOPE), which emphasized communication and conflict resolution, and (b) Forgiveness and Reconciliation through Experiencing Empathy (FREE). HOPE and FREE were compared with repeated assessment controls.

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.

Glycogen synthase kinase (GSK)-3β is a multifunctional protein that has been implicated in the pathological characteristics of Alzheimer's disease (AD), including the heightened levels of neurofibrillary tangles, amyloid-beta (Aβ), and neurodegeneration. In this study we used 12-month-old SAMP8 mice, an AD model, to examine the effects GSK-3β may cause regarding the cognitive impairment and oxidative stress associated with AD. To suppress the level of GSK-3β, SAMP8 mice were treated with an antisense oligonucleotide (GAO) directed at this kinase.

Relationship factors and quality among mixed-orientation couples.

Mixed-orientation couples are defined as a heterosexual couple in which 1 partner experiences same-sex attraction and the other does not. Despite the fact that there is a sizable number of mixed-orientation couples in the U.S.

Operational challenges and solutions with implementation of an adaptive seamless phase 2/3 study.

A wide variety of operational issues were encountered with the planning and implementation of an adaptive, dose-finding, seamless phase 2/3 trial for a diabetes therapeutic. Compared with a conventional design, significant upfront planning was required, as well as earlier, more integrated cross-functional coordination. The existing infrastructure necessitated greater flexibility to meet the needs of the adaptive design.

Morphological and quantitative changes in paternal brood-pouch vasculature during embryonic development in two Syngnathus pipefishes.

Vascular corrosion casts of Syngnathus floridae and Syngnathus fuscus brood pouches were examined by scanning electron microscopy. Morphological and quantitative data on the vasculature of the paternal brood pouch during each stage of embryonic development were investigated to explore potential changes during brooding, to consider interspecific differences and to provide structural evidence for previously reported functional roles of the brood pouch. The brood pouches of both species are highly vascularized structures with cup-like arrangements of brood-pouch vasculature developing around each embryo shortly after fertilization and breaking down before fry release.

Elevated whole brain arginine vasotocin with Aroclor 1254 exposure in two Syngnathus pipefishes.

The neurohypophysial hormone arginine vasotocin (AVT) and the neuroendocrine system strongly interact with the rest of the teleostean endocrine system. The aim of this study is to investigate the effects of exposure to an endocrine disruptor on whole brain AVT concentrations for the pipefishes Syngnathus floridae and S. fuscus.

Quantification of whole brain arginine vasotocin for two Syngnathus pipefishes: elevated concentrations correlated with paternal brooding.

Arginine vasotocin (AVT) regulates many aspects of fish physiology and behavior including courtship and reproduction. This study begins to address whether paternal functions for AVT have independently evolved in species in which paternal behavior has evolved. We quantified AVT in the brains of Syngnathus fuscus and Syngnathus floridae which, like other pipefishes and seahorses of the family Syngnathidae, brood embryos within specialized structures of the male.

Osmoregulatory role of the paternal brood pouch for two Syngnathus species.

Even though sea horses, sea dragons, and pipefishes of the teleost family Syngnathidae have been studied for over a century, the physiological significance of the paternal brood pouch is not well defined. Here we document the regulation of brood pouch osmolality during embryonic development for Syngnathus floridae and Syngnathus fuscus, particularly during the middle brood stages or around hatching. S.

Direct evidence for embryonic uptake of paternally-derived nutrients in two pipefishes (Syngnathidae: Syngnathus spp.).

Seahorses, sea dragons and pipefishes of the teleost family Syngnathidae are unique in that embryos develop within specialized brooding structures of the male. We enriched brooding Syngnathus fuscus and Syngnathus floridae males with injections of L-lysine-[(15)N(2)] and 16:0-palmitic acid 1-[(13)C] to demonstrate embryonic uptake of paternally-derived nutrients. While all embryos demonstrated amino acid enrichment, late stages showed significantly higher [(15)N], indicating greater utilization of paternal resources as yolk reserves diminished and embryonic energy demands increased.

Utilization of protein expression profiles as indicators of environmental impairment of smallmouth bass (Micropterus dolomieu) from the Shenandoah River, Virginia, USA.

The Shenandoah River (VA, USA), the largest tributary of the Potomac River (MD, USA) and an important source of drinking water, has been the site of extensive fish kills since 2004. Previous investigations indicate environmental stressors may be adversely modulating the immune system of smallmouth bass (Micropterus dolomieu) and other species. Anterior kidney (AK) tissue, the major site of blood cell production in fish, was collected from smallmouth bass at three sites along the Shenandoah River.

Influence of estuarine hypoxia on feeding and sound production by two sympatric pipefish species (Syngnathidae).

This research utilizes the acoustic behavior of two sympatric pipefish species to assess the impact of hypoxia on feeding. We collected northern, Syngnathus fuscus, and dusky pipefishes, Syngnathus floridae, from the relatively pristine Chincoteague Bay, Virginia, USA and audiovisually recorded behavior in the laboratory of fish held in normoxic (>5 mg/L O(2)) and hypoxic (2 and 1 mg/L O(2)) conditions. Both species produced high frequency ( approximately 0.

Differential parental nutrient allocation in two congeneric pipefish species (Syngnathidae: Syngnathus spp.).

Male seahorses and pipefishes of the family Syngnathidae are heralded for their unique brood pouch structures for incubating embryos. There are three general types of brood pouch with increasing complexity: simple ventral gluing, two pouch flaps and a completely sealed sac. The diversity of functional roles within a type in providing nutrition, aeration and protection to offspring is unknown.

Randomized trial of a low-intensity dietary intervention in rural residents: the Rural Physician Cancer Prevention Project.

Background: Dietary behavior, specifically a low-fat, high-fiber diet, plays a role in the primary prevention of chronic diseases including cancer.

Design: A community-based randomized trial to assess the impact of a low-intensity, physician-endorsed, self-help dietary intervention that provided tailored dietary feedback, and was designed to promote improved fat and fiber behavior in a rural, low-education/low-literacy, partly minority population. The data were collected from 1999 to 2003.

Coordinating care for the dual-eligible population.

Many patients who are eligible for Medicare also are eligible for Medicaid. IDSs that deliver care to these patients, called "dual eligibles," face a challenge of conflicting rules and incentives under existing Federal and state laws governing coverage of these patients. Differences in the Medicare and Medicaid payment rules give IDSs a financial incentive to transfer patients from long-term and postacute to acute care settings in situations in which the patients might receive more appropriate care remaining where they are.

Immune responses and protection induced by mucosal and systemic immunisation with recombinant measles nucleoprotein in a mouse model of measles virus-induced encephalitis.

In this study the immunogenicity of recombinant nucleoprotein (Np) administered intranasally or intraperitoneally, and its ability to support a systemic protective anti-virus antibody response was examined, in a mouse model of measles virus (MV)-induced encephalitis. Although both intranasal and intraperitoneal routes of immunisation resulted in priming Np- and MV-specific T-cell responses, the intraperitoneal route was shown to prime for a predominantly IgG2a serum anti-MV antibody response of high avidity, which confered complete protection following intracranial challenge with a neuroadapted strain of MV. On the other hand, intranasal priming resulted in a mixed IgG1, IgG2a serum anti-MV antibody response of low avidity, and only 43% of immunised mice survived following intracranial challenge with the neuroadapted strain of MV.