[Cytogenetic changes of the bone marrow in massive blood loss and their correction with mexidol].

The citogenetic lesions were evaluated in the marrow erythroblasts of 45 anesthetized white nonlinear male rats, weight--200-300 g who were subjected to an acute blood loss with a 1-hour arterial hypotension (ABR = 40 mm Hg); the micronucleus tests was made use of. Two stages of the increase of polychromatophilic erythrocytes with micronuclei in the marrow of the animals, who underwent a massive blood loss, were registered: stage 1--an incomplete marrow ischemia with a subsequent arterial hypotension and with a reliably confirmed formation of cytogenetic lesions in the marrow polychromatophilic erythrocytes; stage 2--the reperfusion period contributed to a 1.7-fold increase of polychromatophilic erythrocytes with micronuclei versus the previous stage.

[Study of the antiradical and radioprotective properties of S-containing compounds using the complex of in vitro test-systems].

Capability of S-radioprotectors (AET, 2-AT, 2-ADT) to react with OH-radicals and to protect various molecular biotest systems against radiation damage was compared with that of 5-methoxytryptamine, some amino acids and t-butanol. A method of competing acceptors was used to determine rate constants in reactions of the radioprotectors with OH-radicals. A complex of biotest systems (protein, DNA, protein-lipid complex) was applied to estimate the radioprotective activity in vitro.

[Effect of ionizing radiation on the structure of human serum albumin. Effect of irradiation on the content of free amino groups and on the ability of HSA to be digested by proteinases].

The effect of gamma-quanta on human serum albumin (HSA) solutions (1.6 mg/ml, borate buffer pH 7.45) in the air has been investigated.