Publications by authors named "Rioufol G"

Background: Temporary transvenous pacing (TTP) is a common procedure, predominantly performed in the catheterization laboratory (cath lab) because of presumed lower complication rate. This study aims to evaluate the efficacy and safety of TTP placement in the ICU compared to TTP placement in the cath lab.

Methods: This retrospective, real-life study included all patients requiring TTP in a tertiary care ICU between 2019 and 2022.

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Background: Jailed wire (JW) in the side branch (SB) is recommended during coronary bifurcation provisional stenting, but there is uncertainty about the real benefit. Our objective was to evaluate the benefit of a JW technique in the Coronary Artery Bifurcation Revascularization Without kIssing ballOon infLation by rEpoT (CABRIOLET) registry.

Methods: In CABRIOLET, which included 500 patients, we compared the primary composite end point of a poor final SB angiographic result (of Thrombolysis in Myocardial Infarction (TIMI) flow < III, dissection grade > B, thrombosis, residual stenosis > 70%, or additional SB stenting) whether JW was performed or not.

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  • The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
  • Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
  • The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
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Transcatheter closure of a patent foramen ovale (PFO) is performed in cryptogenic stroke and other conditions. Information is lacking for some devices. We aimed to evaluate the Figulla Flex II PFO Occluder (FFP) and Figulla Flex UNI Occluder (FFU) through a retrospective multi-center registry.

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  • Re-POT (proximal optimization technique) is a new method for treating coronary bifurcation lesions, showing better artery outcomes compared to traditional techniques, and has proven good short-term results.
  • The CABRIOLET registry studied the long-term benefits of the Re-POT method in a diverse group of 500 patients across five European centers, focusing on complications like target lesion failure over a year.
  • Results indicated a low rate of target lesion failure (2.0%) and target lesion revascularization (1.6%) after one year, suggesting that the Re-POT technique is a safe and effective option for patients with various types of bifurcation lesions.
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Objective: Left atrial appendage closure (LAAC) is recommended to decrease the stroke risk in patients with atrial fibrillation and contraindications to anticoagulation. However, age-stratified data are scarce. The aim of this study was to provide information on the safety and efficacy of LAAC, with emphasis on the oldest patients.

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  • The PFO-AF study aims to investigate the onset and recurrence of atrial fibrillation (AF) in patients who have undergone a procedure to close a patent foramen ovale (PFO) after suffering a stroke, utilizing implanted cardiac monitors for accurate data collection.
  • It will involve 250 patients and track AF occurrences two months before and up to two years after the PFO closure, focusing on monitoring any AF episodes recorded by the cardiac device.
  • The study is ethically approved and its results will be shared at conferences and in scientific journals to contribute to the understanding of AF in this patient population.
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  • Management of thrombus during primary percutaneous coronary intervention (pPCI) is crucial to prevent complications like stent malapposition, especially at coronary bifurcations, leading to the development of a new experimental model to study thrombus behavior.
  • In the study, three pPCI strategies were tested on a bifurcation model using human blood to analyze their effects on thrombus trapping and embolization: balloon-expandable stent (BES), BES with proximal optimizing technique (POT), and nitinol self-apposing stent (SAS).
  • Results showed that while BES trapped more thrombus than SAS or BES+POT, both SAS and BES+POT provided significantly better stent apposition, suggesting that
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Background: Intra-atrial reentrant tachycardia (IART) is a frequent arrhythmia in patients with Fontan circulation. Although its supraventricular origin, such arrhythmia can be poorly tolerated as it leads to haemodynamic impairment. Concomitant assessment of pressure/volume overload of cardiac chambers due to valvular disease or residual shunts is necessary.

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Background: Transcatheter aortic valve implantation now has a major role in the treatment of patients with severe aortic stenosis. However, evidence is scarce on its feasibility and safety to treat patients with pure aortic regurgitation.

Aims: We sought to evaluate the results of transcatheter aortic valve implantation using the balloon-expandable SAPIEN 3 transcatheter heart valve (Edwards Lifesciences, Irvine, CA, USA) in patients with pure aortic regurgitation on native non-calcified valves.

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  • Optical Coherence Tomography (OCT) has evolved as a key imaging tool over the past two decades, significantly improving our understanding of coronary atherosclerosis and optimizing cardiac interventions.
  • Recent advancements in OCT have enabled better identification of plaque pathology and healing processes in patients with acute coronary syndromes, potentially transforming patient management.
  • This Review aims to present the latest insights on cardiac OCT, standardizing its clinical application and interpretation among researchers and clinicians globally.
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The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has increased exponentially. Pulmonary congestion is a potentially life-threatening complication of peripheral VA-ECMO. Recently updated guidelines argue for a low threshold of left ventricular (LV) unloading.

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  • Aging correlates with a chronic low-grade inflammatory state, potentially impacting the acute inflammatory response in conditions like STEMI and AIS.
  • The HIBISCUS-STEMI and HIBISCUS-STROKE studies analyzed inflammatory markers in young (<65 years) and older (≥65 years) patients admitted for these conditions between 2016 and 2019.
  • Results indicated that older patients exhibited higher IL-6 and sTNF-RI levels, lower lymphocyte counts, and higher neutrophil-lymphocyte ratios within the first 24 hours after STEMI or AIS, highlighting a distinct inflammatory profile in older individuals.
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Background Spatial resolution, soft-tissue contrast, and dose-efficient capabilities of photon-counting CT (PCCT) potentially allow a better quality and diagnostic confidence of coronary CT angiography (CCTA) in comparison to conventional CT. Purpose To compare the quality of CCTA scans obtained with a clinical prototype PCCT system and an energy-integrating detector (EID) dual-layer CT (DLCT) system. Materials and Methods In this prospective board-approved study with informed consent, participants with coronary artery disease underwent retrospective electrocardiographically gated CCTA with both systems after injection of 65-75 mL of 400 mg/mL iodinated contrast agent at 5 mL/sec.

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Ventricular septal rupture (VSR) is a serious complication of ST-elevation myocardial infarction (STEMI) and surgery is the reference treatment. We aimed at describing trends in management and mortality during the last four decades and reporting mortality predictors in these patients. We conducted a single-center retrospective study of patients sustaining a VSR from 1981 to 2020.

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Carcinoid heart disease is a rare condition affecting mostly tricuspid and pulmonary valves causing right-sided heart failure. Surgical valve replacement is the mainstay of treatment when patients become symptomatic and/or in the presence of right heart remodeling. We present a case of severe pulmonary valve regurgitation secondary to carcinoid heart disease occurring 4 years after a surgical tricuspid replacement, successfully treated with direct transcatheter pulmonary valve implantation without pre-stenting.

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