Mobile application for first aid to children: a technological innovation in schools.

Objectives: to develop a mobile application for first aid to children, designed for use by basic education professionals.

Methods: we carried out this applied research in three phases: 1-integrative review, 2- identification of learning needs through a cross-sectional study with 53 school professionals, and 3- app development.

Results: the Child and Care (Criança e Cuidado) app includes three main sections (Important contacts, Learn first aid, and Record the accident).

Fecundity of the snapping shrimp Alpheus estuariensis (Caridea: Alpheidae) after the oil spill in three mangroves of tropical Brazil.

This study examined the impacts of oil spills since 2019 by analyzing polycyclic aromatic hydrocarbons (PAHs) in sediments and their effects on the fecundity of the shrimp Alpheus estuariensis. Samples were collected from mangroves in three Pernambuco locations: Catuama, Suape Bay, and Carneiros Beach. Ovigerous females were identified, and their eggs were counted and classified by embryonic stage.

Integrating social data and engineering solutions for developing resilient water infrastructure against coastal climate change.

This study combines responses from a social survey with compound flood modeling in a marginalized coastal community to assess implementation of green infrastructure, such as rain barrels and rain gardens, in a city scale. This research focuses on the City of Imperial Beach, CA, which is an underserved coastal community located near the border with Mexico. A principal objective of the present research was analyzing social survey responses and the public's perceptions to estimate the extent to which decentralized water infrastructure might be accepted by and feasible for the target underserved coastal community.

Active Surveillance of Grade Group 2 Prostate Cancer: Oncological Outcomes from a Contemporary European Cohort.

Background And Objective: Uptake of active surveillance for patients with Gleason grade group (GG) 2 prostate cancer (PCa) remains low. Magnetic resonance imaging (MRI) before biopsy would allow better patient selection, but there are no published data on this strategy. Our aim was to report one of the first European AS series of patients with GG 2 PCa selected via MRI before image-guided biopsy.

Attitudes of polish medical students toward organ donation.

Background: The aim of the study was to analyze determinants affecting attitudes toward organ donation among medical students at medical universities in Poland.

Materials And Methods: The study involved 1,348 medical students. It was performed using a validated questionnaire of attitude toward organ donation and transplantation (ODT) [PCID-DTO RIOS: A questionnaire designed by the International Collaborative Organ Donation project about organ transplantation and donation].

The Establishment of a Terrestrial Macroalga Canopy Impacts Microbial Soil Communities in Antarctica.

Prasiola is a genus of foliose green algae that forms extensive cryptogamic canopies that contribute to the greening of ice-free areas in the Antarctic tundra. To better understand the impact of Prasiola canopy establishment on colonization in these areas, this study compared the taxonomic and functional structures of bacterial and fungal communities in adjacent soils with and without extensive Prasiola colonization. DNA metabarcoding was employed to analyze the microbial community structure in these soils and in the canopy.

Mapping T cell dynamics to molecular profiles through behavior-guided transcriptomics.

The rise of cellular immunotherapy for cancer treatment has led to the utilization of immune oncology cocultures to simulate T cell interactions with cancer cells for assessing their antitumor response. Previously, we developed BEHAV3D, a three-dimensional live imaging platform of patient-derived tumor organoid (PDO) and engineered T cell cocultures, that analyzes T cells' dynamics to gain crucial insights into their behavior during tumor targeting. However, live imaging alone cannot determine the molecular drivers behind these behaviors.

Advances and shortfalls in knowledge of Antarctic terrestrial and freshwater biodiversity.

Antarctica harbors many distinctive features of life, yet much about the diversity and functioning of Antarctica's life remains unknown. Evolutionary histories and functional ecology are well understood only for vertebrates, whereas research on invertebrates is largely limited to species descriptions and some studies on environmental tolerances. Knowledge on Antarctic vegetation cover showcases the challenges of characterizing population trends for most groups.

Peroxisome proliferator-activated receptor alpha is an essential factor in enhanced macrophage immune function induced by angiotensin-converting enzyme.

Increased expression of angiotensin-converting enzyme (ACE) by myeloid lineage cells strongly increases the immune activity of these cells, as observed in ACE10/10 mice, which exhibit a marked increase in antitumor and antibactericidal immunity. We report that peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor that regulates genes critical for lipid metabolism, is a key molecule in the enhanced macrophage function induced by ACE. Here, we used a Cre-LoxP approach with LysM-Cre to create a modified ACE10/10 mouse line in which macrophages continue to generate abundant ACE but in which monocyte and macrophage PPARα expression is selectively suppressed.

Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation.

Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Oxidative phosphorylation sharply decreases upon classical macrophage activation, as mitochondria are thought to shift from ATP production towards accumulating signals that amplify effector function. However, evidence is conflicting regarding whether this collapse in respiration is essential or dispensable.

Hybrid and Plant-Based Burgers: Trends, Challenges, and Physicochemical and Sensory Qualities.

Burgers have become a staple of global cuisine and can have several different versions and combinations. For example, hybrid burgers have a percentage of animal protein in their formulation, while plant-based burgers contain 100% plant-based proteins. Therefore, the aim of this study was to investigate the emerging trends and challenges in the formulation of hybrid and plant-based burgers, with an emphasis on new ingredients and the evaluation of their physical, chemical, and sensory properties.

(Dis)connecting the Globe Through Water-Driven Ecological and Biogeochemical Corridors in the Polar-Alpine Biome.

Global change is causing the melting of ice masses, permafrost thawing, and the shrinking of glaciers, thereby reshaping nature's rhythms. Longer thaw phases and more frequent dry periods are transforming water-driven transitional ecosystems (e.g.

Electrical asymmetrical flow field-flow fractionation: Fundamentals, evolution, applications, and prospects.

Among the plethora of techniques that conforms the Field-Flow Fractionation (FFF) family, electrical field-flow fractionation (ElFFF) was designed to separate different analytes based on their size and electrophoretic mobility (µ). However, major technical and operational issues made this technique to fall into oblivion. Many of those drawbacks can be circumvented if another field is employed as the main driving force for the elution in the same channel, such as the most successful and useful FFF-related technique, asymmetrical flow field-flow fractionation (AF4).

Metabolic regulation of RNA methylation by the mA-reader IGF2BP3.

The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a "reader" of the N6-methyladenosine (mA) modification and crucial for regulating gene expression. Yet, how its function as a reader overlaps with its critical oncogenic function in leukemia remains an open question.

Variations in Trauma Education Practices Across Emergency Medicine Residencies: Insights from a National Survey of Program Directors.

Purpose: Care of the acutely injured trauma patient is integral to the practice of emergency medicine. It is currently unknown how most emergency medicine residencies structure their residents' trauma experience and little guidance for competency assessment is provided by the Residency Review Committee. Our study aimed to determine current emergency medicine residency practices in trauma resuscitation.

Impact of dissolved/dispersed oil from a spill event on the development of embryos of the snapping shrimp Alpheus estuariensis (Caridea: Alpheidae).

This study characterized polycyclic aromatic hydrocarbons (PAHs) in oil pellets stranded at Fernando de Noronha Archipelago, equatorial Atlantic. It also characterized PAHs dissolved/dispersed in seawater (i.e.

Postharvest Quality of Arugula () Microgreens Determined by Microbiological, Physico-Chemical, and Sensory Parameters.

(1) Background: Cultivating microgreens is emerging as an excellent market opportunity. Their easy, short, and sustainable production methods are the main reasons they are approved by growers. However, a feature that still prevents its further spread is the microbiological risk and their rapid senescence.

Adaptive circuits for action and value information in rodent operant learning.

Operant learning is a behavioral paradigm where animals learn to associate their actions with consequences, adapting their behavior accordingly. This review delves into the neural circuits that underpin operant learning in rodents, emphasizing the dynamic interplay between neural pathways, synaptic plasticity, and gene expression changes. We explore the cortico-basal ganglia circuits, highlighting the pivotal role of dopamine in modulating these pathways to reinforce behaviors that yield positive outcomes.

Altered Development of the Hurst Exponent in the Medial Prefrontal Cortex in Preschoolers With Autism.

Background: Atypical balance of excitation (E) and inhibition (I) in the brain is thought to contribute to the emergence and symptomatology of autism spectrum disorder (ASD). E/I ratio can be estimated from resting-state functional magnetic resonance imaging (fMRI) using the Hurst exponent, H. A recent study reported decreased ventromedial prefrontal cortex (vmPFC) H in male adults with ASD.

Prevalence and anti-microbial resistance of spp. isolated from the environment and veterinary personnel in a Spanish veterinary teaching hospital.

Methicillin-resistant (MRS) bacteria, including methicillin-resistant and methicillin-resistant (MRSP), pose a significant threat in veterinary medicine, given their potential for zoonotic transmission and their implications for companion animals and humans' health. This study aimed to assess the prevalence of MRS and anti-microbial resistance patterns at a university clinical hospital in Madrid, Spain. Samples were collected from both the environment and hospital staff at Veterinary Clinical Hospital of Alfonso X el Sabio University.

Response surface methology for enzymatic ultrasound assisted sp-ICP-MS assessment of cuonps in seafood: Occurrence and bioaccumulation.

A novel approach for a reliable extraction and analytical characterization of copper oxide nanoparticles (CuONPs) at trace levels on seafood samples was tuned up using single particle inductively coupled plasma mass spectrometry (sp-ICP-MS). Variables for enzymatic extraction of CuONPs were optimised via response surface methodology (RSM) analysis, to maximize both the extracted CuONPs mass and number concentrations without altering their native size and morphology. Analytical performance features of the whole (enzymatic ultrasound-assisted/sp-ICP-MS) approach were thoroughly evaluated.