Publications by authors named "Rion Yamazaki"
Muscle-invasive bladder cancer (MIBC), a highly heterogeneous disease, shows genomic instability and a high mutation rate, making it difficult to treat. Recent studies revealed that cancer stem cells (CSCs) play a critical role in MIBC frequent recurrence and high morbidity. Previous research has shown that Cyclooxygenases-2 (COX-2) is particularly highly expressed in bladder cancer cells.
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- Triple-negative breast cancer (TNBC) is challenging to treat, with cancer stem cells (CSCs) contributing to its recurrence and spread.
- Researchers developed a new adenoviral vector (Ad-CD44-N-HIF-3α4) that harnesses a synthetic Notch receptor to target CSCs by using CD44 as a decoy, effectively disrupting cancer cell signals.
- In mouse studies with a highly invasive TNBC cell line, the injection of this vector showed promising antitumor effects, suggesting it could be a potential treatment for TNBC patients.