Publications by authors named "Rio Takezawa"
Article Synopsis
- * A follow-up colonoscopy after 5 months showed significant changes in the colon, now suggesting active ulcerative colitis rather than Crohn's disease.
- * Genetic testing revealed specific mutations, and treatment with colchicine led to complete clinical remission, indicating a possible link to familial Mediterranean fever and highlighting the importance of monitoring changes in colonic inflammation for accurate diagnosis.
Article Synopsis
- The study compares two bowel cleansing methods for colonoscopy preparation: Sodium picosulfate/magnesium citrate (SP/MC) and polyethylene glycol (PEG) with ascorbic acid, with a focus on patient acceptability and effectiveness.
- The trial includes 540 participants aged 40-69 and evaluates bowel cleansing quality using the Boston Bowel Preparation Scale, along with other factors like patient satisfaction and detection of polyps.
- Researchers aim to demonstrate that SP/MC is not only more acceptable due to its smaller dosage and better taste but also as effective as PEG for ensuring thorough bowel cleansing in outpatient settings.
Article Synopsis
- A new endoscopic gastric cancer screening program was initiated in Kurashiki city, focusing on infection status based on endoscopic features, to evaluate its feasibility in a prospective study involving 1784 participants.
- The study found that 68.1% of subjects showed no gastritis, while 26.3% had active or inactive gastritis, with an endoscopic false-negative rate of 16.3% when compared to a serum test method.
- Although endoscopic assessments are generally reliable, the presence of mild gastric atrophy may lead to false negatives, prompting researchers to suggest incorporating antibody tests to improve diagnostic accuracy.
Background And Aim: Duodenal ulcer bleeding has a higher risk of mortality than bleeding from other portions of the gastrointestinal tract. AIMS65 is an effective risk-scoring system to predict prognosis of upper gastrointestinal bleeding and can be easily calculated without endoscopic findings. In this study, we investigate the usefulness of AIMS65 to predict prognosis of patients with duodenal ulcer bleeding.
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- A pilot study was conducted to evaluate the safety and effectiveness of using cold forceps biopsy (CFB) to remove very small pharyngeal lesions, which are 3 mm or smaller in size.
- The study involved 39 lesions, with the primary focus on the rate of local recurrence after three months, as well as determining risk factors and potential adverse events associated with the procedure.
- Results showed a 20% endoscopic recurrence rate and 16.7% pathological recurrence rate, with high-grade dysplasia found in a significant portion of the lesions, suggesting CFB is both safe and effective for treating these types of neoplasms.
Article Synopsis
- Antithrombotic therapy increases the risk of delayed bleeding after endoscopic submucosal dissection (ESD) for gastric tumors, and vonoprazan is being investigated as a potential alternative to conventional proton pump inhibitors (PPIs) for prevention.
- A study involving 50 patients treated with vonoprazan showed a delayed bleeding incidence of 16.0%, which was not significantly different from a historical control group using PPIs (12.1%).
- Factors associated with delayed bleeding included age over 70, use of multiple antithrombotic drugs, longer procedure time, and larger tumor size, while vonoprazan showed no significant benefit compared to PPIs in this context.
Article Synopsis
- The study aimed to determine if submucosal saline injection during cold snare polypectomy (CSP) for small colorectal polyps could improve resection depth for better pathologic evaluation.
- Conducted as a randomized trial with 214 patients, the results showed no significant difference in complete muscularis mucosae (MM) resection rates between CSP with saline injection (CSP-SI) and conventional CSP (C-CSP).
- Interestingly, the CSP-SI method resulted in lower rates of negative lateral and vertical margins, suggesting it may be less effective despite no major complications reported.
Article Synopsis
- Newly published guidelines from the Japanese Gastroenterological Endoscopy Society (JGES) suggest proceeding with endoscopic procedures without stopping warfarin and stopping direct oral anticoagulants (DOACs) only on the day of the procedure.
- A study analyzed the medical records of 344 patients who underwent hot-snare polypectomy while on anticoagulants, comparing post-polypectomy bleeding rates between those following the new guidelines and those who had anticoagulants interrupted with heparin-bridging.
- Results indicated that the bleeding rates in patients following the new guidelines were not significantly different from those who had their anticoagulants interrupted, supporting the validity of JGES recommendations for managing anticoagulant therapy during polypectomy.
[Endoscopic features of AL amyloidosis:one case of localized upper gastrointestinal amyloidosis].
Nihon Shokakibyo Gakkai Zasshi
September 2019
Article Synopsis
- The study investigates the adequacy of cold snare polypectomy (CSP) in removing small colorectal polyps and ensuring they can be properly assessed for advanced neoplasia.
- Researchers analyzed 376 polyps, finding that 6.6% had unexpected advanced histology and identified factors like fragmentation and incomplete muscularis mucosae resection that could hinder accurate evaluation.
- The study concludes that sessile polyps and those located in the cecum have higher risks of incomplete removal and fragmentation, which can negatively impact histological assessment.
Background: Cold polypectomy has been widely accepted for removal of small colorectal polyps. However, no large-scale prospective study exists as for its safety in Japan. We investigated this issue in this single-center, prospective cohort study in a total of 1198 colorectal polyps resected with cold polypectomy.
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