Roles of lysophosphatidic acid (LPA) receptor-2 (LPA) in the regulation of cellular responses induced by X-ray irradiation and hydrogen peroxide in pancreatic cancer cells.

Purpose: Lysophosphatidic acid (LPA) receptor-mediated signaling regulates various biological functions in cancer cells. This study aimed to evaluate the roles of LPA receptor-2 (LPA) in cellular responses induced by X-ray irradiation in pancreatic cancer PANC-1 cells. Since X-ray irradiation generates reactive oxygen species (ROS), PANC-1 cells were treated with hydrogen peroxide (HO).

Effects of free fatty acid receptor-2 (FFAR2)-mediated signaling on the regulation of cellular functions in osteosarcoma cells.

G protein coupled free fatty acid receptors (FFARs) are involved in the pathogenesis of several human diseases. FFAR2 and FFAR3 are activated by the binding of short-chain fatty acids (SCFAs). This study aimed to evaluate the roles of FFAR2 in the regulation of cellular functions in osteosarcoma HOS cells, using acetic acid and propanoic acid as FFAR2 and FFAR3 agonists.

Effects of lysophosphatidic acid (LPA) signaling via LPA receptors on cellular functions associated with ATP reduction in osteosarcoma cells treated with ethidium bromide.

Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA to LPA) exhibits a variety of malignant properties in cancer cells. Intracellular ATP depletion leads to the development of necrosis and apoptosis. The present study aimed to evaluate the effects of LPA receptor-mediated signaling on the regulation of cancer cell functions associated with ATP reduction.

Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA) and LPA in osteosarcoma cells.

Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA to LPA) exhibits a variety of biological responses. In tumor microenvironment, endothelial cells promote cancer cell functions. In this study, we investigated the roles of endothelial cells in the regulation of cell motile activity via LPA and LPA in human osteosarcoma MG-63 cells.

Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA) signaling enhances cancer cell survival to cisplatin.

Lysophosphatidic acid (LPA) through six subtypes of G protein-coupled LPA receptors (LPA to LPA) mediates a variety of cancer cell functions. The aim of this study was to evaluate the cooperative effects of G12/13 and Gi proteins through LPA on cancer cell survival to cisplatin (CDDP). In cell survival assay, cells were treated with CDDP every 24 h for 2 days.