Thin Layer Chromatography-Freeze Surface-Enhanced Raman Spectroscopy: A Powerful Tool for Monitoring Synthetic Reactions.

Thin layer chromatography (TLC) is widely used to confirm the formation of the target compound in chemical synthesis. The key issue in TLC is spot identification as it primarily relies on retention factors. Coupling of TLC with surface-enhanced Raman spectroscopy (SERS), which gives direct molecular information, is an appropriate choice, to overcome this challenge.