An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which does not necessarily reflect the identity and function of pathogenic senescent cells in vivo. Here, we developed a new pipeline leveraging a fluorescent murine reporter that allows for isolation and quantification of p16Ink4a+ cells in diseased tissues.

Risks from solar-powered groundwater irrigation.

Emissions reductions may not meet expectations, and groundwater use will likely increase.

Balancing national economic policy outcomes for sustainable development.

The 2030 Sustainable Development Goals (SDGs) aim at jointly improving economic, social, and environmental outcomes for human prosperity and planetary health. However, designing national economic policies that support advancement across multiple Sustainable Development Goals is hindered by the complexities of multi-sector economies and often conflicting policies. To address this, we introduce a national-scale design framework that can enable policymakers to sift through complex, non-linear, multi-sector policy spaces to identify efficient policy portfolios that balance economic, social, and environmental goals.

Irrigation improves weight-for-height z-scores of children under five, and Women's and Household Dietary Diversity Scores in Ethiopia and Tanzania.

Evidence on the potential for agricultural intensification to improve nutrition has grown considerably. While small-scale irrigation is a key factor driving agricultural intensification in sub-Saharan Africa, its impact on nutrition has not yet been thoroughly explored. In this study, we assess the impact of adoption of small-scale irrigation in Ethiopia and Tanzania on household and women's dietary diversity, as well as children's nutrition.

Seasonal variation in maternal dietary diversity is reduced by small-scale irrigation practices: A longitudinal study.

Some agricultural practices, such as irrigation, have the potential to buffer seasonal dietary gaps and through increased production and consumption improve diets, particularly of the rural poor relying on subsistence farming but also for rural and urban households purchasing irrigated produce on local markets. The study aimed to evaluate the effect of seasonality and irrigation on women's diet in rural Ethiopia. Using a longitudinal study design, three rounds of surveys were conducted among women of reproductive age (15-49 years).

Perspective: The Importance of Water Security for Ensuring Food Security, Good Nutrition, and Well-being.

Water security is a powerful concept that is still in its early days in the field of nutrition. Given the prevalence and severity of water issues and the many interconnections between water and nutrition, we argue that water security deserves attention commensurate with its importance to human nutrition and health. To this end, we first give a brief introduction to water insecurity and discuss its conceptualization in terms of availability, access, use, and stability.

Quantifying the Sustainability of Water Availability for the Water-Food-Energy-Ecosystem Nexus in the Niger River Basin.

Water, food, energy, and the ecosystems they depend on interact with each other in highly complex and interlinked ways. These interdependencies can be traced particularly well in the context of a river basin, which is delineated by hydrological boundaries. The interactions are shaped by humans interacting with nature, and as such, a river basin can be characterized as a complex, coupled socioecological system.

An overture to overeating: The cross-modal effects of acoustic pitch on food preferences and serving behavior.

Billions of dollars are spent annually with the aim of enticing consumers to purchase food. Yet despite the prevalence of such advertising, little is known about how the actual sensation of this advertising media affects consumer behavior, including consequential choices regarding food. This paper explores the effect of acoustic pitch in food advertising, demonstrating in two studies, including a field study in a live retail environment, how the perception of pitch in advertising can impact food desirability and decisions regarding serving size.

The role of Latin America's land and water resources for global food security: environmental trade-offs of future food production pathways.

One of humanity's major challenges of the 21st century will be meeting future food demands on an increasingly resource constrained-planet. Global food production will have to rise by 70 percent between 2000 and 2050 to meet effective demand which poses major challenges to food production systems. Doing so without compromising environmental integrity is an even greater challenge.

Agro-ecology, household economics and malaria in Uganda: empirical correlations between agricultural and health outcomes.

Background: This paper establishes empirical evidence relating the agriculture and health sectors in Uganda. The analysis explores linkages between agricultural management, malaria and implications for improving community health outcomes in rural Uganda. The goal of this exploratory work is to expand the evidence-base for collaboration between the agricultural and health sectors in Uganda.

Adapting agriculture to climate change in Kenya: household strategies and determinants.

Countries in Sub-Saharan Africa are particularly vulnerable to climate change, given dependence on agricultural production and limited adaptive capacity. Based on farm household and Participatory Rural Appraisal data collected from districts in various agroecological zones in Kenya, this paper examines farmers' perceptions of climate change, ongoing adaptation measures, and factors influencing farmers' decisions to adapt. The results show that households face considerable challenges in adapting to climate change.