Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA.

Background: The efficacy of a novel oral combination product, Simparica Trio™, containing sarolaner, moxidectin and pyrantel was evaluated against five tick species that commonly infest dogs in the USA, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis and Rhipicephalus sanguineus.

Methods: Laboratory studies were conducted against two different strains of each tick species. In each study, 10 purpose-bred Beagle or mixed-breed dogs were randomly allocated to one of two treatment groups based on pre-treatment host-suitability tick counts.

Constraining the minute amount of audible energy radiated from binary collisions of light plastic spheres in conditions of incomplete angular coverage of the measured pressure.

Usually, the energy released as air-coupled sound following a collision is dismissed as negligible. The goal of this Letter is to quantify the value of this small but measurable quantity, since it can be useful to impact studies. Measurements of sound radiation from binary collisions of polypropylene balls were performed in order to constrain the fraction of incident energy radiated as sound in air.

Non-Hertzian behavior in binary collisions of plastic balls derived from impact acoustics.

This paper presents slight deviations from Hertz's impact law, inferred from acoustic signatures of polypropylene ball collisions. An impact acoustics model is used to fit the acoustic data. The model is built upon a generalized relationship between impact force (F) and deformation (xi) of the form F=kappaxi(alpha).

Ovicidal and larvicidal modes of action of fenoxycarb against the cat flea (Siphonaptera: Pulicidae).

The mode of action of the insect growth regulator, fenoxycarb, on embryogenesis of cat flea eggs, Ctenocephalides felis (Bouché), was evaluated biologically and morphologically. Newly oviposited flea eggs were aged for 0, 3, 6, 12, 24, 48, or 72 h and exposed to fenoxycarb (1.1 micrograms/cm2) on filter paper disks for 0 (60 s), 2, 4, 8, 12, or 24 h at 23 +/- 1 degree C and 70 +/- 3% RH.

Comparative efficacy of injection routes and doses of ivermectin against Psoroptes in rabbits.

Rabbits infested with Psoroptes ovis (Hering) or with P cuniculi (Delafond) were injected IM or subcutaneously with ivermectin or with vehicle. A single injection of ivermectin (200 micrograms/kg) either IM or subcutaneously was inadequate to eliminate all mites in the ears of the rabbits. However, a single injection of ivermectin at 400 micrograms/kg, regardless of the route of injection, eliminated all P cuniculi mites, but eliminated P ovis mites in only 50% of the rabbits.

Cross-mating studies with Psoroptes ovis (hering) and Psoroptes cuniculi delafond (Acarina: psoroptidae).

Reciprocal cross-matings of Psoroptes ovis and P. cuniculi occurred and produced viable offspring through the F2 generation. Hybrids of these crosses were infective to both rabbits and cattle.

Influence of density and location on degradation of sustained-release boluses given to cattle.

To better understand the factors involved in erosion of sustained-release ruminal boluses, studies were conducted to determine the relationship between density of the bolus and location in the forestomachs and the influence of these factors on bolus erosion. Boluses with densities of 1.2, 1.

Chemoprophylaxis of vector-borne anaplasmosis with sustained-release boluses.

Sustained-release oxytetracycline boluses (20%) delivering 145 to 150 mg/bolus/day were administered to complement-fixation test-negative cattle at dosages of 2.0, 2.5, and 3.

Effects of daily oral subtoxic doses of a wet lead-based paint on cattle.

Cattle were dosed daily with a wet lead-based paint at a rate of about 6 mg of lead per kg per day for 60 weeks. The cattle did not exhibit overt symptoms of lead toxicosis. Blood and fecal samples collected during the study, and tissue samples obtained at slaughter of the animals were analyzed for lead by atomic absorption spectrophotometer equipped with a graphite furnace.