Publications by authors named "Rinat Lifshitz-Shovali"
Article Synopsis
- Bone sialoprotein (BSP) and osteopontin (OPN) are key factors in breast cancer metastasis, and targeting them with siRNA significantly reduced cell migration and osteolytic lesions in a study with human breast cancer cells in rats.
- The research highlighted the effectiveness of biodegradable nanoparticles (NP) for local siRNA delivery, which improved treatment outcomes and reduced skeletal lesions more efficiently compared to traditional systemic methods.
- Overall, the study demonstrates that siRNA targeting can effectively impair cancer cell migration and offers a promising strategy for developing new treatments using nanoparticles.
Efficient and specific delivery of antisenses (ASs) and protection of the sequences from degradation are critical factors for effective therapy. Sustained release nanoparticles (NP) offer increased resistance to nuclease degradation, increased amounts of AS uptake, and the possibility of control in dosing and sustained duration of AS administration. The biodegradable and biocompatible poly(D,L-lactic-co-glycolic acid) copolymer (PLGA) was utilized to encapsulate AS directed against osteopontin (OPN), which is a promising therapeutic target in mammary carcinoma.
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