Characterizing the involvement of the nuclear factor-kappa B (NF kappa B) transcription factor in uveal melanoma.

Purpose. To examine the involvement of nuclear factor-kappa B (NFkappaB) pathways in uveal melanoma (UM) and to assess their potential as a therapeutic target for metastatic UM. Methods.

Molecular characteristics of liver metastases from uveal melanoma.

Purpose: The liver is the most common site of systemic metastases from uveal melanoma (UM). Such metastases usually continue to develop despite the application of current treatment modalities. This study was conducted to obtain insight into the molecular pathways that underlie the development of UM metastasis and thus to identify potential novel therapeutic pathways for this disease.