Publications by authors named "Rinat A Yusupov"
Background: Data on the genetic factors contributing to inter-individual variability in muscle fiber size are limited. Recent research has demonstrated that mice lacking the Arkadia (RNF111) N-terminal-like PKA signaling regulator 2N (; also known as ) gene exhibit reduced muscle fiber size, contraction force, and exercise capacity, along with defects in calcium handling within fast-twitch muscle fibers. However, the role of the gene in human muscle physiology, and particularly in athletic populations, remains poorly understood.
View Article and Find Full Text PDFThe greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown.
View Article and Find Full Text PDFInsertions and deletions (indels) are the second most common type of variation in the human genome. However, limited data on their associations with exercise-related phenotypes have been documented. The aim of the present study was to examine the association between 18,370 indel variants and power athlete status, followed by additional studies in 357,246 individuals.
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- * A study of 2,479 individuals indicated that T allele carriers had a significantly higher presence among chess players and PhD holders in STEM fields compared to controls, suggesting a genetic association with cognitive performance in these domains.
- * Notably, all international chess grandmasters in the study did not carry the CC genotype, indicating a strong correlation between carrying the T allele and high-level achievement in chess and science.
Article Synopsis
- Brisk walkers have better physical fitness, body composition, and muscle strength, prompting a study on genetic variants linked to increased walking speed among elite sprinters versus controls.
- The analysis involved 70 genetic markers from a large study and focused on 137 Russian elite sprinters compared to 126 controls, using advanced genotyping methods.
- The study identified 15 genetic variants positively associated with being a sprinter, with one variant linked to more fast-twitch muscle fibers, and showed that having more favorable alleles increases the odds of being an elite sprinter significantly.
Article Synopsis
- A study identified 28 genetic variations linked to strength athletes, but further research is needed to confirm these findings through genotype-phenotype studies.
- The research involved 53 elite Russian and 100 sub-elite Japanese weightlifters, checking how specific genetic markers affected their lifting performance.
- Four particular genetic alleles were found to correlate positively with better weightlifting results, and those with more strength-related alleles consistently performed better in competitions across both Russian and Japanese athletes.