Publications by authors named "Rina Nunokawa"
Article Synopsis
- DBP is a key transcription factor that controls daily physiological rhythms by regulating genes with a specific DNA motif, but the exact way its protein levels fluctuate throughout the day is not well understood.
- This study found that DBP protein levels are down-regulated by the ubiquitin-proteasome pathway, specifically through enzymes UBE2G1 and UBE2T, which promote DBP degradation.
- TRAF7, an E3 ligase identified in the study, enhances the degradation of DBP and influences the circadian clock, suggesting it plays a significant role in stabilizing DBP levels based on the time of day.
