A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum.

Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon.

A Rare Case of Occult Advanced Uterine Adenocarcinoma With a Neoplastic Enterouterine Fistula on Presentation.

Enterouterine fistula is a rare complication of endometrial carcinoma, typically associated with a clinical presentation of malodorous vaginal discharge. We present a case of occult metastatic endometrial cancer with an initial presentation of embolic stroke, further complicated by an incidental finding of enterouterine fistula on imaging. This case uniquely describes a patient with no symptoms suggestive of uterine malignancy or enterouterine fistula, highlighting a rare presentation of this occult malignancy and further emphasizing the importance of preventative screening.

Volumetric parameters from [ F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms.

A positive fluorine-18 labelled 2-deoxy-2-fluoroglucose ([ F]FDG) positron emission tomography/computed tomography (PET/CT) has been associated with more aggressive disease and less differentiated neuroendocrine neoplasms (NEN). Although a high maximum standardized uptake value (SUV ) predicts poor outcome in NEN, volumetric parameters from [ F]FDG PET have not been evaluated for prognostication in a pure high-grade gastroenteropancreatic (GEP) NEN cohort. In this retrospective observational study, we evaluated the volumetric PET parameters total metabolic tumour volume (tMTV) and total total lesion glycolysis (tTLG) for independent prognostication of overall survival (OS).

Applications of Hybrid PET/Magnetic Resonance Imaging in Central Nervous System Disorders.

PET with 18F-fluorodeoxyglucose (FDG) is used to assess a wide array of inflammatory and neoplastic disorders. FDG-PET has shown particular utility in the evaluation of disorders of the central nervous system (CNS). Although fused PET/computed tomography (CT) is frequently used across the globe for these diseases, recent evidence has pointed to PET/magnetic resonance (MR) imaging as a more sensitive and specific molecular imaging modality.

Atypical clinical and radiological presentation of multiple sclerosis: A case report.

A 59-year-old, previously healthy Caucasian female patient presented to the ED with a sudden onset of focal neurological deficit, with stable vital signs. Her initial physical examination revealed left-sided facial nerve palsy and right lower extremity weakness. The CT head was negative for intracranial bleeding.