Efficacy and Safety of Elective Switching from Intravenous to Subcutaneous Infliximab [CT-P13]: A Multicentre Cohort Study.

Background: Intravenous [IV] infliximab is a well-established therapy for inflammatory bowel diseases [IBD] patients. A subcutaneous [SC] formulation of infliximab [CT-P13] has recently been shown to be as effective as IV infliximab after two doses of IV induction in a randomised trial, but there are no data to support elective switching of patients on maintenance IV infliximab therapy. We aimed to assess the effectiveness of an elective switching programme to SC CT-P13 in patients treated with IV infliximab.

A temporal model for nonelite triathlon race injuries.

Objective: To (1) classify types and severity of injuries, (2) establish a temporal model for both the incidence and prevalence of injuries, and (3) identify the most appropriate medical manpower needed for nonelite triathlon competition.

Design: Prospective observational study.

Setting: Oklahoma City Redman Triathlon.

The Peterborough scheme for community specialist optometrists in glaucoma: a feasibility study.

Purpose: This study assessed the role of specialist optometrists who were working in the community and sharing the care for glaucoma patients with, and under close supervision of, a consultant ophthalmologist working in the Hospital Eye Services (HES) to ensure high-quality standards, safety, and care.

Methods: From February 2005 onwards, the majority of all new glaucoma referrals to our eye department were diverted to our specialist optometrists in glaucoma (SOGs) in their own community practices. Selected patients in the HES setting who were already diagnosed with stable glaucoma were also transferred to the SOGs.

Hydroview lens implant calcification: 186 exchanges at a district general hospital.

Aim: This paper describes the experience at a district general hospital of coping with an abrupt onset of calcification of Hydroview intraocular lens (IOL) implants requiring exchange surgery mostly for symptoms of glare, even though the visual acuities were relatively good.

Methods: In this retrospective study, the operative details of 174 consecutive lens exchanges by one surgeon were retrieved from the surgeon's notes. Of these, pre and post-operative details of 106 consecutive patients were obtained from the hospital notes.

Have a nice day.

Today's NHS is dynamic, multifaceted and complex, and the task of delivering care is not easy. Receiving care is a profoundly personal experience and perceptions of the quality of care being offered are highly individual. As part of their endeavours to measure the quality of service being offered at Maesteg Community Hospital, South Wales, the staff of the day hospital wanted to obtain the views of the older people who attended.

Prevalence of primary open angle glaucoma in general ophthalmic practice in the United Kingdom.

Aim: To estimate the predicted prevalence of primary open angle glaucoma (POAG) from the activity of a local ophthalmology department.

Method: Using clinic audit data, the local incidence and prevalence of POAG in the registered population of two primary care trusts were calculated.

Results: The local derived prevalence estimate for POAG was 978 per 100 000 people aged 40-89 years (95% CI 753 to 1272) compared with the expected prevalence from a published model of 1230 people per 100 000 people aged 40-89 years.

Cataract surgery and the optometrist.

Purpose: To determine the outcome of discharge on the first day following cataract surgery and the feedback from patients' optometrists.

Methods: Casenotes of patients who had cataract surgery between 1 April 1997 and 30 June 1998 were analysed. Patients without complications were discharged on day 1 and advised to see their optometrist at 1 month.

The effect of perioperative embolisation on visual function in patients undergoing carotid endarterectomy.

Objectives: To investigate the effect of carotid artery embolisation detected by transcranial Doppler (TCD) monitoring during carotid endarterectomy (CEA) on visual function.

Design: A prospective study. Visual function was assessed by an independent ophthalmalogist.

Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group.

Purpose: Most uveitis case series have come from tertiary care centers, and the relative frequencies of disorders they report may reflect referral bias. We sought information about the types of uveitis encountered in the general practice of ophthalmology.

Methods: We prospectively examined 213 consecutive cases of general uveitis, defined as intraocular inflammation other than cytomegalovirus retinopathy, seen by a group of community-based comprehensive ophthalmologists.

Effects of hypoxemia on the electroretinogram in diabetics.

Purpose: To identify any relationship between retinal dependence on oxygen and the presence or absence of retinopathy in a group of patients with the same duration of diabetes, based on the proposal that diabetic retinopathy results from long-term adaptation to the Crabtree effect, i.e., reduction of oxidative phosphorylation caused by increased intracellular glucose concentrations.

Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus.

1. An increase in capillary blood flow and pressure has been implicated in the pathogenesis of diabetic microangiopathy. Abnormal vascular reactivity of the resistance vasculature may play a contributory role by permitting alterations in regional haemodynamics.