Dual-aptamer-decorated reduction-activated dimeric-prodrug nanoparticles for broad-spectrum treatment of leukemia.

Leukemia remains a fatal disease for most affected patients, and a simple and effective therapeutic strategy is urgently needed. Targeted delivery chemo-drugs to leukemia cells shows promise, but the diverse subtypes of leukemia make single-ligand nanomedicine often ineffective. Herein, a dual-aptamer decorated, reduction-responsive dimeric prodrug-based nanoparticle (NP), termed SXP-NPs, was developed using the two leukemia-specific aptamers Sgc8c and XQ-2d, a reduction-responsive podophyllotoxin (POD) dimeric prodrug, and DSPE-PEG2000.

Engineering Metal-Organic Frameworks for the Electrochemical Reduction of CO : A Minireview.

The electrochemical reduction of CO holds great promise for lowering the concentration of CO in the Earth's atmosphere. However, several challenges have hindered the commercialization of this technology, including energy efficiency, the solubility of CO in the aqueous phase, and electrode stability. In this Minireview, we highlight and summarize the main advantages and limitations that metal-organic frameworks (MOFs) may offer in this field of research, either when used directly as electrocatalysts or when used as catalyst precursors.

Metal-Organic-Framework-Mediated Nitrogen-Doped Carbon for CO Electrochemical Reduction.

A nitrogen-doped carbon was synthesized through the pyrolysis of the well-known metal-organic framework ZIF-8, followed by a subsequent acid treatment, and has been applied as a catalyst in the electrochemical reduction of carbon dioxide. The resulting electrode shows Faradaic efficiencies to carbon monoxide as high as ∼78%, with hydrogen being the only byproduct. The pyrolysis temperature determines the amount and the accessibility of N species in the carbon electrode, in which pyridinic-N and quaternary-N species play key roles in the selective formation of carbon monoxide.

Prevalence and genetic diversities of hantaviruses in rodents in Beijing, China.

A total of 835 rodents captured in Beijing, China, were tested for hantavirus infection. Fifty-five (6.6%) were positive for viral RNA when lung tissue samples were examined by reverse transcriptase-polymerase chain reaction.

[Study on the association between hantavirus infection and Rattus norvegicus].

Objective: To further understand the association of hantavirus (HV) harbored and transmitted in wild brown rats.

Methods: Rattus norvegicus (n = 570) were trapped in 10 sites in Beijing. RT-PCR was used to test rodent lung samples for hantavirus infection.

[Investigation on hantaviruses infection in rodents from free markets in Beijing areas].

Objective: In order to find out the factors related to hemorrhagic fever with renal syndrome (HFRS) infection, and to evaluate the probability of ecdemic hantaviruses (HV) infection in rodents in Beijing areas.

Methods: Rodents were collected in a large-scale railway station and a produce market with 'trap nights' method from April to May, 2004. The IgG reacting sera to HV antigen were detected using ELISA.