Measurement of histological clearance margins in basal cell carcinoma.

Aims: Basal cell carcinoma (BCC) is a common cancer, with a high risk of local recurrence. A quantifiable measurement of the histological margins of BCC in excisions is a recurrent demand of clinicians; however, there are currently no international guidelines indicating its value.

Methods And Results: A questionnaire validated by four experts in dermatopathology and formatted under a 'Google Forms'-type interface was sent by e-mail to physicians specializing in surgical pathology or dermatopathology and practising in France from 20 March 2018 to 20 May 2018.

Association between clinicopathological characteristics and RAS mutation in colorectal cancer.

In colorectal cancer, KRAS (exons 2, 3, and 4) and NRAS (exons 2, 3, and 4) mutations are associated with resistance to antiepidermal growth factor receptor monoclonal antibodies, and BRAF mutation is a molecular marker of poor prognosis. KRAS exon 2 and BRAF-mutated colorectal cancers have well-known distinct clinicopathological characteristics. Comparison of tumors with different RAS status (exons 2, 3, and 4 of KRAS and NRAS) based on their clinicopathological characteristics has never been established.

Identification and characterization of the iron compounds in bone marrow by means of Mössbauer spectrometry.

In order to determine and to demonstrate the cellular iron molecular states in hematopoietic bone marrow, direct investigations were performed by means of different and complementary spectroscopic techniques: optical absorption, electron spin resonance and Mössbauer spectrometry. In fact, the latter appears to have been the most informative. In addition to the hemoglobin forms, five- and six-coordination ligand protoporphyrins IX (monomeric and polymeric stacking, respectively) were observed.

Relationship between parietal blood flow studies in the left colon and the rectum in dogs. Colonic pressure and blood flow.

An animal model was proposed to clarify the difference in occurrence of enterocolitis in congenital aganglionosis. When gaseous distention of the colon was localized to the rectosigmoid area, enterocolitis never occurred. On the contrary, when it involved the left colon, enterocolitis occurred in 13 of 15 patients.

Mössbauer spectroscopy study of iron overloaded livers.

Absorption 57Fe Mössbauer spectra have been carried out directly on fresh or lyophylized tissues of liver with either normal iron depot or iron overload. Two types of overloading have been studied: primary iron overload due to an excessive intestinal iron absorption and secondary iron overload (hemosiderosis) produced in beta-thalassemia patients by hypertransfusional therapeutics. The Mössbauer spectra, at room temperature, 77 and 4.

X-irradiation effect on human red cells: hemoglobin study by Mössbauer spectrometry.

This work is a study of the radioinduced transformations undergone by intraglobular hemoglobin. Mössbauer spectrometry allows us to study in a wide range of doses the effect of X rays on deoxyhemoglobin as well as on oxyhemoglobin. Using this technique we have shown large differences between these two derivatives of hemoglobin.

Mössbauer spectroscopy and perturbed angular correlation studies of the rare-and alkaline-earth bone uptake.

Emission Mössbauer spectra and Perturbed Angular Correlation measurements have been performed on samples of mineral bone powder labelled with 161Tb3+ or 133Ba2+ ions after either in vitro absorption or uptake by metabolic pathway. The study of these hyperfine spectra, compared with those carried out when 161Tb or 133Ba are situated in either hydroxyde lattice or phosphate one, shows that the uptake modes of rare-and alkaline-earth ions on the bone matrix are different. The rare earth ion seems to be absorbed on the surface bone in an environment of hydroxyl groups similar to the structure of a rare earth hydroxyde.

Time differential perturbed angular correlation (TDPAC) studies of the 133Ba ion uptake in bone crystals.

TDPAC measurements of the 356-81 keV gamma-ray cascade resulting from electron capture decay of 133Ba have been performed at room temperature on BaCl2 (aqueous solution and polycrystalline powder), and on samples where the 133Ba nucleus is bound to bone powder, and also to synthesised hydroxylapatite, all after absorption in vitro. As expected, the angular correlation is not perturbed in the solution. However, in the polycrystalline chloride the time dependence of the anisotropy of the cascade of 133Cs nuclide indicates that the decaying nucleus undergoes electric interactions due to different electric field gradients acting at the site of the nucleus.

Vasomotor origin of intracranial pressure waves in hydrocephalic infants.

By measuring cerebral blood volume (CBV) and intracranial pressure (ICP) variations at the same running time during sleep, it has been demonstrated that the ICP wave which appears during the REM sleep in hydrocephalic infants is produced by intracerebral vaso-dilatation. Nine infants with stabilized hydrocephalus were investigated by non-invasive means: REM phases were distinguished with the usual polysomnographic electrodes. Intracranial pressure was measured with a fontanel palpation transducer and CBV variations were obtained by recording 99mTc activity at the head level after in vivo labelling of red cells with 99mTc--pertechnetate.

[Sleep polygraphy with recording of intracranial pressure and measure of cerebral blood volume in hydrocephalic infants (author's transl)].

This study was carried with the intention of explaining the causes of modifications in intracranial pressure (ICP) during paradoxical sleep (PS) in normal and hydrocephalic infants, and establishing relationships between these modifications and cerebral blood volume (CBV). All tests (conventional sleep polygraphy, ICP measured by a transducer on the fontanel, CBV measured by isotopic labelling of red blood cells in vivo) were carried out without use of surgical procedures. During paradoxical sleep there was a sustained wave of increased intracranial pressure lasting from 10 to 20 minutes, as well as phase-type variations lasting no longer than 1 minute.

[Quantitation of mitral and aortic regurgitation using the effective systemic ejection fraction measured by radiocardiography and scintography of the cardiac cavities].

Comparison between the effective systemic ejection fraction defined by radiocardiography and cardiac chambers scanning, and the whole left ventricular ejection fraction calculated by cineangiocardiography allows an accurate assessment of mitral and aortic regurgitation extent. In case of both mitral and aortic insufficiency, each regurgitation can be quantitatively dissociated by means of the aortic isotopic dilution curve recorded at the same time as the radiocardiogram.