Publications by authors named "Rima Manafi"
Background: Hemophilia B, or Christmas disease, is a hemorrhagic inherited disorder. Previous studies have reported measurement discrepancies in factor VIII activity between clot-based and chromogenic assays in approximately one-third of patients with non-severe hemophilia A. However, similar discrepancies in hemophilia B have been less extensively studied.
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- B cell precursor acute lymphoblastic leukemia (BCP-ALL) is prevalent in children, but recent therapies have improved the cure rate to 80%, highlighting the need for less toxic treatment options.
- Indole-3-carbinol (I3C), found in cruciferous vegetables, has shown promise as it inhibits cell growth and induces apoptosis in BCP-ALL cells, affecting key proteins involved in the cell cycle and apoptosis pathways.
- Combining I3C with doxorubicin, a standard treatment, enhances the cytotoxic effects while reducing harmful side effects, suggesting a potential new approach for treating childhood BCP-ALL with less toxicity.