Regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element.

Background: Antimicrobial resistance is a growing international problem. We observed a 50% increase in the prevalence of trimethoprim resistance among fecal Escherichia coli from healthy Nigerian students between 1998 and 2005, a trend to increase that continued in 2009.

Methods And Findings: A PCR-based screen revealed that 131 (43.

Carriage of diarrhoeagenic Escherichia coli by older children and adults in Accra, Ghana.

Diarrhoeagenic Escherichia coli (DEC) were sought in stool specimens from 72 adults and children aged over 3 years, who presented with diarrhoea at a hospital in Accra, Ghana, and 72 matched controls. Only diffusely-adherent E. coli were significantly associated with disease in these older individuals (P=0.