Publications by authors named "Rim Jenni"

Ataxia Telangiectasia (AT) is a rare multisystemic neurodegenerative disease caused by biallelic mutations in the ATM gene. Few clinical studies on AT disease have been conducted in Tunisia, however, the mutational landscape is still undefined. Our aim is to determine the clinical and genetic spectrum of AT Tunisian patients and to explore the potential underlying mechanism of variant pathogenicity.

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Unlabelled: Currently, clinical biomarkers are urgently needed to improve patient management to guide personal therapy for cancer. In this study, we investigate the deregulation of in prostate cancer (PC) Tunisian patients. Expression patterns of the were investigated in prostate adenocarcinoma and benign prostate biopsies using quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR) and 2-ΔΔCt method.

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Research in normal tissue radiobiology is in continuous progress to assess cellular response following ionizing radiation exposure especially linked to carcinogenesis risk. This was observed among patients with a history of radiotherapy of the scalp for ringworm who developed basal cell carcinoma (BCC). However, the involved mechanisms remain largely undefined.

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Background: Angiotensin-converting enzyme (ACE) plays a pivotal role in several pathologies including cancers. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. We aimed to investigate for the first time, to our Knowledge, in North Africa the potential relationship between ACE I/D polymorphism with PC susceptibility and clinical outcomes of PC patients.

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Article Synopsis
  • - The study investigates how specific genetic variations (SNPs) in the XPC gene, which is involved in DNA repair, may affect the risk of developing prostate cancer (PC) among the Tunisian population.
  • Results indicate that while the XPC Lys939Gln variant doesn’t increase cancer risk, individuals with the XPC PAT I/I genotype have a significantly higher risk of developing prostate cancer (3.83 times more likely) compared to controls.
  • No strong connections were found between the XPC gene variations and clinical factors like Gleason score, TNM status, or lifestyle factors such as tobacco use and alcohol consumption.
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