Publications by authors named "Rim Hussein-Agha"
Article Synopsis
- HSCT is the only curative treatment for patients with short telomere syndromes and severe bone marrow failure or myeloid malignancies, but the effectiveness is influenced by their sensitivity to the conditioning regimen.
- In a study involving adults and adolescents treated with an alemtuzumab-based regimen, outcomes showed a low 2-year graft rejection-free survival (GRFS) rate for those with myeloid malignancies (20%) compared to other patients (57%).
- While the overall 2-year overall survival (OS) was quite favorable at 66%, the findings suggest that alternative treatment strategies may be necessary for patients with myeloid malignancies.
The extrafollicular immune response is essential to generate a rapid but transient wave of protective antibodies during infection. Despite its importance, the molecular mechanisms controlling this first response are poorly understood. Here, we demonstrate that enhanced Cxcr4 signaling caused by defective receptor desensitization leads to exacerbated extrafollicular B-cell response.
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