Prognosis Associated with Complete Pathological Response Following Neoadjuvant Treatment for PancreaTic AdenOcarciNOma in the FOFLIRINOX Era: the Multicenter TONO Study.

Background: The use of multiagent FOLFIRINOX chemotherapy for pancreatic adenocarcinoma in a neoadjuvant setting has been associated with an increased rate of complete pathological response (CPR) after surgery. This study investigated the long-term outcomes of patients with CPR in a multicenter setting to identify prognostic factors for overall survival (OS) and recurrence-free survival (RFS).

Methods: This retrospective cohort study examined biopsy-proven pancreatic adenocarcinomas with CPR after neoadjuvant chemotherapy or chemoradiotherapy and surgery, between January 2006 and December 2023 across 22 French and  2 Belgian centers.

Flow signatures and catchment's attributes for HCA clustering in a hydrologic similarity assessment (Tunisian case).

Partitioning methods such as cluster analysis are advantageous in pooling catchments into hydrometric similar regions. They help overcome data shortage in ungauged catchments, which is a common problem in Sud Mediterranean zones. Without accurate forecasts, it is difficult to assess and manage water resources efficiently this situation won't be of any assistance to hydrology decision-makers.

Optics in Africa: introduction.

Africa has a long history in optics, but decades of turmoil have seen optical science in Africa advance only slowly, punching far below its weight. But a younger generation of scientists hold promise for the brighter future, addressing continental issues with photonics. In this Feature Issue on Optics in Africa we capture some of the exciting optical research from across the continent in 51 research reports, covering both fundamental and applied topics.

Risk and Predictors of Postoperative Morbidity and Mortality After Pancreaticoduodenectomy for Pancreatic Neuroendocrine Neoplasms: A Comparative Study With Pancreatic Ductal Adenocarcinoma.

Objectives: Pancreaticoduodenectomy (PD) is associated with a high risk of postoperative complications and mortality. The aim of this study was to compare postoperative morbidity after PD in patients undergoing resections for pancreatic neuroendocrine neoplasms (PanNENs) with patients undergoing the same resection for pancreatic ductal adenocarcinoma (PDAC).

Methods: Data of 566 patients from 3 European tertiary referral centers between 1998 and 2014 were considered.

Clinical and body composition predictors of bone turnover and mineral content in obese postmenopausal women.

The purpose of this study was to determine the predictors of bone mineral density (BMD), bone mineral content (BMC), and bone turnover markers in obese postmenopausal women. In this cross-sectional study, 81 postmenopausal women aged 58.40 ± 6.

Mid-infrared supercontinuum generation in multimode As Se chalcogenide photonic crystal fiber.

We rigorously investigated the mid-infrared supercontinuum generation in a multimode AsSe chalcogenide photonic crystal fiber (PCF). We studied the impact of the intermodal nonlinear effects on the nonlinear propagation of the fundamental and high-order modes. By solving the multimode generalized nonlinear Schrödinger equation, we have predicted the generation of a very broadband supercontinuum in both polarizations of the fundamental mode spanning from 2 to 11 μm at -20  dB in only 5 cm PCF length.

Positive Association of Obesity and Insulin Resistance With Bone Mineral Density in Tunisian Postmenopausal Women.

The association of bone mineral density (BMD) with obesity and insulin resistance remains unclear. This study aimed to explore these associations in Tunisian menopausal women. Eighty-one postmenopausal women were recruited.

Dual-energy X-ray absorptiometry underestimates in vivo lumbar spine bone mineral density in overweight rats.

Dual-energy X-ray absorptiometry (DXA) is currently the most widely used technique for measuring areal bone mineral density (BMD). However, several studies have shown inaccuracy, with either overestimation or underestimation of DXA BMD measurements in the case of overweight or obese individuals. We have designed an overweight rat model based on junk food to compare the effect of obesity on in vivo and ex vivo BMD and bone mineral content measurements.

Super-flat coherent supercontinuum source in AsSe chalcogenide photonic crystal fiber with all-normal dispersion engineering at a very low input energy.

We numerically report super-flat coherent mid-infrared supercontinuum (MIR-SC) generation in a chalcogenide AsSe photonic crystal fiber (PCF). The dispersion and nonlinear parameters of AsSe chalcogenide PCFs by varying the diameter of the air holes are engineered to obtain all-normal dispersion (ANDi) with high nonlinearities. We show that launching low-energy 50 fs optical pulses with 0.

Rigorous study of supercontinuum generation in few mode fibers.

We numerically studied supercontinuum (SC) generation in a few-mode photonic crystal fiber (PCF). We have shown the impact of the intermodal nonlinear effects that could limit the fundamental mode nonlinear propagation due to the coupling induced by high-order optical modes. We have demonstrated an accurate modeling of the SC generation into the multimode PCF by solving the multimode generalized nonlinear Shrödinger equation (MM-GNLSE).

Laparoscopic Pancreaticoduodenectomy with Reconstruction of the Portal Vein with the Parietal Peritoneum.

Introduction: Laparoscopic pancreaticoduodenectomy (LPD) is increasingly used for resections of periampullary tumors, including pancreatic adenocarcinoma.1 LPD with venous resection-reconstruction (VRR) has already been performed with or without vascular graft.2 (,) 3 The parietal peritoneum (PP) was recently described for reconstruction of the mesenterico-portal vein, with excellent results.

Sporadic nonfunctioning pancreatic neuroendocrine tumors: prognostic significance of incidental diagnosis.

Background: Sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed as incidentalomas, and their resection is usually recommended. The prognostic significance of this diagnosis feature is poorly studied, and management of these tumors remains controversial. Clinical, pathologic characteristics and outcome of resected incidentally diagnosed NF-PNET (Inc) were compared with resected symptomatic NF-PNET (Symp) to better assess their biologic behavior and tailor their management.

Pattern and clinical predictors of lymph node involvement in nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs).

Importance: Nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) are often indolent neoplasms without lymph node (LN) metastasis at diagnosis. Therefore, in patients with low risk of LN metastasis, the extent of surgery and lymphadenectomy could be limited and follow-up adjusted to the very low risk of relapse.

Objective: To construct a predicting model to assess the risk of pN+ prior to surgical resection for NF-PanNETs using preoperative retrievable variables.

Parenchyma-sparing resections for pancreatic neuroendocrine tumors.

Background: Parenchyma-sparing pancreatectomy (PSP), including enucleation and central pancreatectomy, has been investigated as an alternative to standard resection for pancreatic endocrine neoplasm, but the benefit/risk of these procedures remains little known.

Methods: From 1998 to 2010, among 197 patients operated for well-differentiated pancreatic neuroendocrine tumors, 67 underwent PSP (45 enucleations and 22 central pancreatectomies) and 66 standard resections (35 pancreaticoduodenectomies and 31 distal pancreatectomies) for a tumor below 4 cm, without synchronous distant metastasis. Groups were compared regarding postoperative morbidity, mortality, long-term pancreatic function, and survival calculated using the Kaplan-Meier method.

Soliton-self compression in highly nonlinear chalcogenide photonic nanowires with ultralow pulse energy.

We design As2Se3 and As2S3 chalcogenide photonic nanowires to optimize the soliton self-compression with short distances and ultralow input pulse energy. We numerically demonstrate the generation of single optical cycle in an As2S3 photonic nanowire: a 5.07 fs compressed pulse is obtained starting from 250 fs input pulse with 50 pJ in 0.