Publications by authors named "Riley Waters"
Article Synopsis
- The study aimed to validate a simple EMR-based SEPSIS score designed to predict sepsis outcomes in a large cohort of patients across multiple hospitals in Toronto, addressing the limitations of existing scores.
- It involved a retrospective analysis of patients admitted with sepsis over two time periods, assessing in-hospital mortality, ICU admission, and length of stay, with the SEPSIS score incorporating four lab-based predictors.
- The findings revealed that the SEPSIS score had comparable effectiveness to established scoring systems (qSOFA and NEWS2) in predicting mortality and other significant clinical outcomes, suggesting its utility in clinical settings.
Objective: Patient data repositories often assemble medication data from multiple sources, necessitating standardization prior to analysis. We implemented and evaluated a medication standardization procedure for use with a wide range of pharmacy data inputs across all drug categories, which supports research queries at multiple levels of granularity.
Methods: The GEMINI-RxNorm system automates the use of multiple RxNorm tools in tandem with other datasets to identify drug concepts from pharmacy orders.
To explore the role of peptide conformation on catalytic activity in the context of ester hydrolysis catalysts, pairs of sequences were designed that contained or lacked β-hairpin character. For the hydrolysis of -nitrophenylacetate in aqueous media, we found small but consistent trends wherein His-containing sequences based on a scaffold showed higher catalytic activity without β-hairpin character.
View Article and Find Full Text PDF