Publications by authors named "Riley M Williams"
Article Synopsis
- Severe influenza A virus can cause serious issues like lung damage and breathing problems, and there are currently no good medicines to treat it.
- A new drug called UH15-38 has been created to stop a harmful process (called necroptosis) that makes the lung problems worse during severe infections.
- Tests showed that UH15-38 helped reduce lung inflammation and saved lives in infected patients, even when given later in the illness, making it a promising option for treating severe influenza and related conditions.
Article Synopsis
- A small number of cancer patients respond well to immune checkpoint blockade (ICB) therapies, with the RNA-editing enzyme ADAR1 playing a significant role in resistance by suppressing immunogenic double-stranded RNAs (dsRNAs).
- Depleting or mutating ADAR1 leads to the accumulation of Z-form dsRNAs (Z-RNAs), which activates the Z-RNA sensor ZBP1 and triggers necroptosis, a form of programmed cell death.
- A small molecule called curaxin CBL0137 has been found to activate ZBP1 directly, which could help revive immune responses in cancers that typically resist ICB treatment, offering a potential new therapeutic strategy.
Viruses, including members of the herpes-, entero-, and morbillivirus families, are the most common cause of infectious encephalitis in mammals worldwide. During most instances of acute viral encephalitis, neurons are typically the initial cell type that is infected. However, as replication and spread ensue, other parenchymal cells can become viral targets, especially in chronic infections.
View Article and Find Full Text PDFGenomic material from many neurotropic RNA viruses (e.g., measles virus [MV], West Nile virus [WNV], Sindbis virus [SV], rabies virus [RV], and influenza A virus [IAV]) remains detectable in the mouse brain parenchyma long after resolution of the acute infection.
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