[On the issue of separate designation of the pre-Descemet's layer in the structure of the cornea].

The five-layer structure of the cornea has been generally accepted in anatomy for the last 70 years. Since the beginning of 2000, publications about lamellar keratoplasty have appeared, in which during the operation it was necessary to isolate the Descemet's membrane (DM). Several options for the formation of a big bubble have been described; in the most frequently used type, the presence of remnants of thin stromal tissue on the isolated DM were found.

[Modern approaches to the treatment of meibomian gland dysfunction].

The eyelids are a delicate and complex dynamic structure with primary function to protect the eye surface. The term «meibomian gland dysfunction» (MGD) first appeared in the mid-1980s. This lesion is known to result in a disturbance of the tear film, eye irritation symptoms, clinically significant inflammation and diseases of the eye surface.

Effect of mipomersen on LDL-cholesterol in patients with severe LDL-hypercholesterolaemia and atherosclerosis treated by lipoprotein apheresis (The MICA-Study).

Background And Aims: In this study, we evaluated the effect of mipomersen in patients with severe LDL-hypercholesterolaemia and atherosclerosis, treated by lipid lowering drugs and regular lipoprotein apheresis.

Methods: This prospective, randomized, controlled phase II single center trial enrolled 15 patients (9 males, 6 females; 59 ± 9 y, BMI 27 ± 4 kg/m) with established atherosclerosis, LDL-cholesterol ≥130 mg/dL (3.4 mmol/L) despite maximal possible drug therapy, and fulfilling German criteria for regular lipoprotein apheresis.