Publications by authors named "Riko Higashiseto"
Cell Tissue Res
April 2024
Article Synopsis
- ATF5 is a transcription factor crucial for the differentiation and survival of sensory neurons in mouse olfactory organs, yet its specific target genes were previously unknown.
- Chromatin immunoprecipitation-quantitative polymerase chain reaction (ChIP-qPCR) experiments identified Nhlh1 as a novel target gene for ATF5, showing that ATF5 binds to its enhancer region and influences its expression.
- The study suggests that ATF5, along with the co-factor Lhx2, plays a vital role in regulating Nhlh1 to promote the development of olfactory and vomeronasal sensory neurons.
