Improved magnetic drug targeting with maximized magnetic forces and limited particle spreading.

Background: In magnetic drug targeting (MDT), micro- or nanoparticles are injected into the human body to locally deliver therapeutics. These magnetic particles can be guided from a distance by external magnetic fields and gradients from electromagnets.

Purpose: During the particles' movement through the vascular network, they are affected by magnetic forces, fluid (drag) forces, particle interactions, diffusion, etc.

Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery.

Magnetic drug targeting (MDT) is an application in the field of targeted drug delivery in which magnetic (nano)particles act as drug carriers. The particles can be steered toward specific regions in the human body by adapting the currents of external (electro)magnets. Accurate models of particle movement and control algorithms for the electromagnet currents are two of the many requirements to ensure effective drug targeting.