Publications by authors named "Rikke Hindsgaul Harders"
CED-1 (cell death abnormal) is a transmembrane receptor involved in the recognition of "eat-me" signals displayed on the surface of apoptotic cells and thus central for the subsequent engulfment of the cell corpse in Caenorhabditis elegans. The roles of CED-1 in engulfment are well established, as are its downstream effectors. The latter include the adapter protein CED-6/GULP and the ATP-binding cassette family homolog CED-7.
View Article and Find Full Text PDFArticle Synopsis
- * The study reveals that dynein, a motor protein, facilitates communication between engulfing cells and apoptotic germ cells in the C. elegans germline, influencing the process of apoptosis.
- * Findings highlight that dynein light and heavy chains are essential for proper apoptosis, as their absence disrupts the localization of key apoptotic proteins, suggesting that better understanding of this interaction could lead to new treatments for diseases linked to cell death and engulfment issues.