Publications by authors named "Rikke Brix Olsen"
Bone pain is a serious and debilitating symptom of multiple myeloma (MM) that impairs the quality of life of patients. The underlying mechanisms of the pain are unknown and understudied, and there is a need for immunocompetent preclinical models of myeloma-induced bone pain. The aim of this study was to provide the first in-depth behavioral characterization of an immunocompetent mouse model of MM presenting the clinical disease features: osteolytic bone disease and bone pain.
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- - The study investigates how cancer-induced bone pain affects burrowing behavior in mice and rats, which is a natural behavior sensitive to chronic pain.
- - After being inoculated with breast cancer cells, the rodents exhibited decreased bone density and reduced limb use, confirming the presence of the disease.
- - The results show that burrowing performance diminished over time in both models, suggesting that burrowing tests are valuable for evaluating cancer-induced bone pain in research.