Genistein enhances NAD biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes.

A decrease in the NAD level in adipocytes causes adipose-tissue dysfunction, leading to systemic glucose, and lipid metabolism failure. Therefore, it is necessary to develop small molecules and nutraceuticals that can increase NAD levels in adipocytes. Genistein, a nutraceutical derived from soybeans, has various physiological activities and improves glucose and lipid metabolism.