Publications by authors named "Rikako Oki"

Article Synopsis
  • The study focuses on the impact of SARS-CoV-2 on kidney transplant (KTx) recipients, highlighting limited data on their treatment and prognosis during the pandemic.
  • Out of 282 KTx patients infected with the virus, 6.7% experienced severe outcomes, with certain underlying health conditions increasing the risk of complications.
  • Treatment strategies evolved over time in response to new variants, with antiviral drugs being administered as they gained approval.
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Article Synopsis
  • Solid organ transplant (SOT) recipients show poor antibody production against SARS-CoV-2 post-vaccination, raising concerns about their immune responses.
  • A study involving 614 SOT recipients vaccinated with mRNA vaccines revealed an overall seropositivity rate of 43% one month after the second dose, increasing to 70% by six months.
  • Kidney, lung, and simultaneous pancreas-kidney transplant recipients had lower antibody levels at 3 and 6 months compared to other organ types, indicating slower antibody acquisition relative to the general population.
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Background: The number of marginal living kidney donors has increased. Medically complex donors who have hypertension, older age, or low estimated glomerular filtration rate (eGFR) have been more likely to be used.

Methods: We conducted a retrospective cohort study of living kidney donors at a single center.

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Background: There are limitations in treating advanced prostate cancer (PC), especially castration-resistant (CR) cases, in renal transplant recipients (RTRs). We describe the case of RTR with metastatic CRPC (mCRPC) treated with docetaxel.

Case Report: A 60-year-old man with end-stage renal disease due to autosomal-dominant polycystic kidney disease (ADPKD) underwent living-related kidney transplantation.

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Objective: Myostatin, which is known as a negative skeleton muscle regulator, is associated with mortality in maintenance hemodialysis patients. However, the significance of serum myostatin concentrations at dialysis initiation has not been established. We investigated the relation between serum myostatin concentrations and mortality or hospitalization within 1 year in incident dialysis patients.

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Article Synopsis
  • The study focuses on comparing the immunogenicity of the COVID-19 vaccines BNT162b2 and mRNA1273 in solid organ transplant (SOT) recipients who are on immunosuppressive medication.
  • A total of 623 SOT recipients participated, with a final analysis comparing 100 participants who received each vaccine.
  • Results showed that mRNA1273 had significantly better immunogenicity compared to BNT162b2, particularly noticeable 3 months after the second dose.
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Recent developments in intensive desensitization protocols have enabled kidney transplantation in human leukocyte antigen (HLA)-sensitized recipients. However, cases of active antibody-mediated rejection (AABMR), when they occur, are difficult to manage, graft failure being the worst-case scenario. We aimed to assess the impact of our desensitization and AABMR treatment regimen and identify risk factors for disease progression.

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Background: Kidney transplantation is a well-established alternative in renal replacement therapy. Compared with hemodialysis, low-immunological-risk kidney transplantation can reduce the medical treatment costs associated with end-stage renal disease. However, there are few reports on whether high-immunological-risk kidney transplantation reduces the financial burden on governments.

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Pregnancy in kidney transplantation (KT) recipients has been challenging because of the high risk of maternal, fetal, and renal complications. Although patients with immunoglobulin A nephropathy (IgAN)-chronic kidney disease (CKD) are at a high risk for hypertension in pregnancy (HIP), the maternal risk in KT recipients with IgAN as the etiology remains unclear. We retrospectively reviewed the medical records of pregnant KT recipients who delivered at our hospital.

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Background: Kidney transplantation (KTx) after urinary tract conversion surgery is extremely difficult due to several complications. In our case, KTx was performed after multiple operative procedures, including diversion urethrostomy.

Case Report: The patient was a 46-year-old woman with a right atrophic kidney, an ectopic opening of the left ureter, and urethral dysplasia since birth.

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A 74-year-old woman with a 34-year history of hemodialysis presented with an intermittent fever, which later coincided with recurrent bilateral shoulder and hip joint pain. Imaging studies suggested amyloid arthropathy, which was histologically confirmed by a synovial biopsy. Increasing β-microglobulin clearance during dialysis alone attenuated the intermittent fever and joint pain, but the symptoms did not disappear until the administration of prednisolone 10 mg/day.

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Frailty is associated with mortality in maintenance dialysis patients. For incident dialysis patients, we used the clinical frailty scale (CFS) to investigate frailty as related to mortality or hospitalization within 2 years. We retrospectively reviewed the medical records of patients initiating hemodialysis or peritoneal dialysis during 2016-2018.

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Proliferative glomerulonephritis with monoclonal immunoglobulin IgG deposits (PGNMID) is an already described form of renal involvement by monoclonal gammopathy. PGNMID is known to recur in kidney allografts. Bortezomib has shown clinical success in the treatment of multiple myeloma.

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Aim: Xanthine oxidoreductase (XOR) is known as an enzyme related to purine metabolism, catalysing the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. We investigated the relationship between plasma XOR activity in stable kidney transplantation (KT) recipients and carotid artery lesions.

Methods: A total of 42 KT patients visiting our outpatient clinic on regular basis were recruited.

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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had clinical success in the treatment of non-small cell lung carcinoma (NSCLC). An effect of this drug on kidney has not been clarified and the occurrence of glomerulonephritis related to EGFR-TKI has rarely been reported. We present the case of a 71-year-old man with NSCLC who developed proteinuria and microscopic hematuria with the rise in a titer of MPO-ANCA, when 2 years and 3 months passed since the initiation of erlotinib, one of oral EGFR-TKI.

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Diarrhea is a common complication in kidney transplant recipients. Common causes of diarrhea include infection, side effect from medication, rejection, and malignancy. A less common but important cause of diarrhea is de novo inflammatory bowel disease (IBD).

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For peritonitis, a serious complication of peritoneal dialysis (PD), we investigated the relation between duration from the sign (PD effluent abnormalities) to treatment with appropriate antibiotics (ST time) and catheter removal. For 62 PD hospital patients, data of PD-related peritonitis (n = 109) were collected retrospectively. We examined ST time and PD catheter removal times using univariate and multivariate analyses.

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Introduction: Catheter-related infections such as exit site infection (ESI) and tunnel infection (TI) are major causes of peritoneal dialysis (PD) discontinuation. For ESI/TI treatment, catheter diversion procedure (CDP) with exit-site renewal for catheter salvage presents an alternative to catheter removal. Nevertheless, CDP capability of improving PD catheter survival remains unclear.

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Article Synopsis
  • Peritoneal dialysis (PD)-related peritonitis is a frequent complication of PD, and a rare but serious complication called nonocclusive mesenteric ischemia (NOMI) can occur, which requires early detection due to its high mortality risk.
  • A case study is presented involving a 70-year-old woman who experienced moderate abdominal pain and low blood pressure, leading to the diagnosis of PD-related peritonitis caused by Pseudomonas putida, complicated by NOMI.
  • Imaging and colonoscopy revealed significant bowel issues, including mucosal hemorrhage and ulcers in the right colon, suggesting that chronic kidney disease and diabetes may have contributed to the patient's susceptibility to NOMI, highlighting the importance of monitoring for abdominal
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Immune checkpoint inhibitors (CPIs), including pembrolizumab, are becoming common oncological treatments. CPIs have been associated with a significant risk of developing immune-related adverse events (irAEs), such as nephritis and interstitial nephritis. However, the occurrence of glomerulonephritis has only rarely been reported.

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Background: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma characterized by proliferation of B cells within small vessels. Herein, we report a case of a 77-year-old man who presented with IVLBCL and massive tumor formation on the aortic wall who was previously diagnosed with sarcoidosis and focal segmental glomerulosclerosis (FSGS). To our knowledge, this is the first reported case of an IVLBCL with aortic tumor formation.

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