Publications by authors named "Rika Tamura"

This study explored the experiences of Japanese fathers with cancer. Twenty-four adult men undergoing cancer treatment and raising minor children (aged ≤ 19 years) participated. Data gathered using semi-structured interviews were analyzed using the grounded theory approach.

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Purpose: We previously demonstrated that the rational pediatric dosage of warfarin can be well-described by a SIZE parameter that includes an allometry exponent of weight. On the other hand, allometry alone is considered to be insufficient to predict drug clearance in neonates and infants. The primary purpose of the present study was to evaluate the effects of incorporation of the maturation process into the analysis model for the dose-response relationship of warfarin in Japanese children.

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Article Synopsis
  • Tadalafil and sildenafil are drugs that inhibit phosphodiesterase type 5, both showing variability in how they act in patients with pulmonary arterial hypertension.
  • The study aimed to determine if tadalafil is a substrate for P-glycoprotein (P-gp), similar to sildenafil.
  • Results showed that tadalafil is indeed a substrate for P-gp, evidenced by different transport rates in specific cell models compared to sildenafil.
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