Publications by authors named "Rika Takaichi"
L1CAM Is a Marker for Enriching Corticospinal Motor Neurons in the Developing Brain.
Front Cell Neurosci
February 2020
Article Synopsis
- The study shows that neurons from mouse embryos can survive in adult brains and connect to the spinal cord, hinting at cell transplantation as a potential method to repair the corticospinal tract (CST).
- Researchers discovered that grafted cells in the adult brain expressed a protein called CTIP2, which is related to axon growth in the CST.
- By isolating L1CAM+ cells, they found these cells were more effective in generating axons compared to other cells, suggesting that sorting these specific cells could enhance efforts to reconstruct the CST.
Endocytosis of the synaptic vesicle is a complicated process, in which many proteins and lipids participate. Phosphatidylinositol 4,5-bisphosphate (PIP(2) ) plays important roles in the process, and the dynamic regulation of this lipid is one of the key events. Synaptojanin is a PIP(2) phosphatase, and dephosphorylation of PIP(2) of the clathrin coated-vesicle results in the uncoating of the vesicle.
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