Publications by authors named "Rika Inose"
Purpose: Mycobacterial liquid culturing typically requires six weeks or longer, primarily because of the slow growth rate of Mycobacterium tuberculosis. This study aimed to evaluate the potential of shortening the duration of mycobacterial liquid culturing in healthcare settings with high prevalence rates of non-tuberculous mycobacteria.
Methods: We retrospectively analyzed the relationship between mycobacterial species and time to positive testing of liquid cultures from sputum samples using the Mycobacteria Growth Indicator Tube system over a 3.
Article Synopsis
- The latest guidelines for treating complex pulmonary disease recommend using azithromycin, but there’s limited data on its effectiveness against specific strains of the pathogen (MAC).
- A study conducted on 318 MAC strains from a Japanese center showed that azithromycin generally has higher minimum inhibitory concentrations (MICs) than clarithromycin, which raises concerns about relying on clarithromycin's susceptibility results to predict azithromycin effectiveness.
- The findings suggest the need for more extensive multicenter studies to better understand azithromycin's MIC distribution and its relationship to treatment outcomes, as this study had a small sample size and limited treatment outcomes.
Efficient automated semi-quantitative urine culture analysis via BD Urine Culture App.
Diagn Microbiol Infect Dis
January 2022
We aimed to assess the clinical utility of BD Kiestra Urine Culture App (UCA). High concordance rates were observed between the urine culture colony counts obtained by medical technologists and those produced using UCA. This application may increase the efficiency of obtaining semi-quantitative urine culture results.
View Article and Find Full Text PDFIntroduction: Rapid antigen detection (RAD) tests are convenient tools for detecting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinics, and testing using saliva samples could decrease the risk of infection during sample collection. This study aimed to assess the accuracy of the SARS-CoV-2 RAD for testing of nasopharyngeal swab specimens and saliva samples in comparison with the RT-PCR tests and viral culture for detecting viable virus.
Methods: One hundred seventeen nasopharyngeal swab specimens and 73 saliva samples with positive results on RT-PCR were used.
Background: The usability of laboratory tests related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critically important for the world undergoing the COVID-19 pandemic. The present study aimed to assess the diagnostic usability of rapid tests for the detection of antibody against SARS-CoV-2 through comparison of their results with the results of reverse transcription polymerase chain reaction (RT-PCR) test for the detection of SARS-CoV-2 genomic RNA and with the results of a quantitative test for antibody detection.
Methods: Serum samples were collected from 18 patients undergoing RT-PCR testing for SARS-CoV-2.
Invasive fungal disease (IFD) is an important infectious complication of hematological disorders, especially in hematopoietic stem cell transplantation recipients. Evidences suggest seasonal and/or geographical variations in the airborne fungal counts and a relationship between those counts and the incidence of IFD. We evaluated the concentrations of indoor airborne fungi quantitated over the course of one year in a hematology ward in Japan.
View Article and Find Full Text PDFNationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility.
J Infect Chemother
September 2019
Article Synopsis
- A nationwide surveillance study on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan was conducted between January 2014 and April 2015 by three medical societies.
- The study evaluated 1534 bacterial strains obtained from diagnosed adult patients with respiratory infections, focusing on various pathogens like Staphylococcus aureus and Streptococcus pneumoniae.
- Results indicated high resistance rates, with 43.6% of Staphylococcus aureus being methicillin-resistant and significant percentages of Haemophilus influenzae showing resistance to ampicillin.
Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.
J Infect Chemother
September 2017
Article Synopsis
- A nationwide study in Japan in 2012 focused on monitoring the antibiotic resistance of bacterial pathogens responsible for respiratory infections in adult patients.
- A total of 1,236 bacterial strains were tested, revealing high resistance rates, including 51.3% methicillin-resistant Staphylococcus aureus and concerning levels of antibiotic resistance in other bacteria like Klebsiella pneumoniae and Pseudomonas aeruginosa.
- The findings highlight the importance of ongoing surveillance to understand and address the increasing resistance of bacterial respiratory pathogens to antimicrobial treatments.
We investigated antimicrobial activities of meropenem and other antibiotics against 164 isolates (41 Escherichia coli, 16 Klebsiella pneumoniae, 7 Enterobacter cloacae, 21 Pseudomonas aeruginosa, 14 methicillin-susceptible Staphylococcus aureus (MSSA), 18 methicillin-resistant Staphylococcus aureus (MRSA), 47 Staphylococcus epidermidis) from blood of the patients admitted to Keio University Hospital between January and October in 2010. Meropenem showed the potent antibacterial activity against Gram-negative bacteria especially and it maintained good broad spectrum antimicrobial activity including resistant strains through 13 years since when we started the investigation. These results indicated the validity of choosing meropenem as a first line antimicrobial agent for serious infectious diseases.
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