Publications by authors named "Rik Ju Lories"
Article Synopsis
- The 'MHC-I-opathy' concept refers to a group of inflammatory diseases linked to the major histocompatibility complex class I, with recognized conditions including spondyloarthritis and psoriasis, all associated with specific genetic variants.
- There is a significant challenge in understanding and treating these disorders due to differences in patient symptoms and insufficient research on the MHC-I pathway.
- The text advocates for a collaborative approach involving diverse medical and research disciplines to standardize disease definitions, explore genetic factors, and improve therapeutic strategies, ultimately aiming to enhance patient care.
Background: The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in vitro and in vivo.
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