No effect of enalapril on progression in autosomal dominant polycystic kidney disease.

Background: Angiotensin-converting enzyme (ACE) inhibitors are capable of reducing proteinuria and microalbuminuria with preservation of renal function in diabetic and non-diabetic renal disease. We designed a study investigating the effect of enalapril on the protection of renal function in autosomal dominant polycystic kidney disease (ADPKD).

Methods: We studied 61 normotensive and 28 hypertensive ADPKD patients.