Publications by authors named "Rijndert Ariese"
Article Synopsis
- - Pediatric MLL-rearranged acute myeloid leukemia (AML) has poor outcomes mainly due to relapse and drug resistance, necessitating new treatment options.
- - Researchers used a drug-repositioning strategy to screen over 4,000 FDA-approved compounds, discovering that pyrvinium pamoate effectively eliminates MLL-rearranged AML cells at concentrations below 1000 nM.
- - Pyrvinium shows a selective decrease in viability for leukemia cells compared to non-leukemic cells and may work by inhibiting mitochondrial respiration, making it a promising candidate for further studies in treating MLL-rearranged AML.
