Publications by authors named "Rijing He"
Equol Alleviates the In Vitro Aging-Induced Disruption of Porcine Oocytes.
Reprod Domest Anim
January 2025
Oocyte quality is crucial for determining the subsequent embryo developmental capacity and reproductive outcomes. However, aging is detrimental to oocyte quality. Previous studies have demonstrated that soy isoflavones have positive effects on the reproductive performance of female pigs.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how equol, an antioxidant derived from soybean flavonoids, impacts the in vitro maturation (IVM) of porcine oocytes, which are often affected by oxidative stress and reactive oxygen species (ROS).
- Results show that 5 μM equol improves oocyte quality by enhancing cumulus cell expansion, polar body extrusion, and embryonic development post-activation, alongside boosting mitochondrial function and lipid accumulation.
- Equol also reduces DNA damage and early cell death by regulating specific proteins, while lowering ROS levels through the NRF2/KEAP1 antioxidant pathway, suggesting it could enhance IVM practices for porcine oocytes.
Alternative splicing (AS) is a pivotal posttranscriptional regulatory mechanism that is involved in embryonic development. However, the roles of AS in specific developmental events, especially the zygotic genome activation (ZGA) of porcine early embryos, remain unclear. In this study, we demonstrated that alternative splicing events (ASEs) were most prevalent in mammalian embryos during ZGA and that skipped exons were the predominant splicing pattern.
View Article and Find Full Text PDF