Publications by authors named "Riina Kutner"
Article Synopsis
- Hereditary breast cancer screenings frequently miss many genetic predispositions at the population level, despite being well-established.
- A national pilot study in Estonia (2018-2021) revealed that a significant number of genetic risk variants exist among women at average risk, with 75% of at-risk breast cancer cases occurring before age 50.
- Participants found genetic risk information valuable, and a well-coordinated project team proved effective in translating research findings into practical medical applications.
Article Synopsis
- Research on mitochondrial metabolism and respiration in solid tumors is advancing, but effective methods for studying these processes remain limited.
- A new method was developed to measure mitochondrial citrate efflux in breast cancer cell lines and human samples, revealing differences in metabolic activity and respiration rates across various cancer types.
- The study found that aggressive breast cancer subtypes exhibited higher citrate efflux and respiration compared to less aggressive ones, highlighting the need for improved cancer models that better mimic human mitochondrial function for more successful translational research.
The aim of this study was to examine past mammography use and mode of detection among breast cancer (BC) patients in Estonia, a country that has low screening coverage and high BC mortality. Women newly diagnosed with primary BC in Estonia in 2008-2010 were interviewed. Determinants of past mammography use and the detection of BC by mammography were studied using multivariate logistic regression.
View Article and Find Full Text PDFBackground: Survival from breast cancer remains lower in Estonia than in most other European countries. More advanced stage and larger tumors that have impact on survival may be a result of delay in seeking help for breast cancer symptoms. The aim of this study was to identify determinants of delayed presentation among breast cancer patients in Estonia.
View Article and Find Full Text PDFThe aim of this study was to analyze quantitatively cellular respiration in intraoperational tissue samples taken from human breast cancer (BC) patients. We used oxygraphy and the permeabilized cell techniques in combination with Metabolic Control Analysis (MCA) to measure a corresponding flux control coefficient (FCC). The activity of all components of ATP synthasome, and respiratory chain complexes was found to be significantly increased in human BC cells in situ as compared to the adjacent control tissue.
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