Publications by authors named "Riho Fukuda"
Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-producing beta cells in pancreatic islets. T lymphocytes are the claimed pathogenic effectors but abnormalities of other immune cell types, including neutrophils, also characterize T1D development. During human T1D natural history, neutrophils are reduced in the circulation, while accumulate in the pancreas where release of neutrophil extracellular traps (NETs), or NETosis, is manifest.
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- * Elevated PNAs were found in the blood of children with T1D and those at risk of developing it, alongside increased markers of inflammation in pancreatic islets of certain mouse models, indicating a link between PNAs and T1D pathogenesis.
- * PNAs might serve as a potential biomarker for early T1D detection, while a drug called methyl cellobiose sulfate (mCBS) has shown promise in reducing histone-induced damage to islet cells in