Phantom energy in the nonlinear response of a quantum many-body scar state.

Quantum many-body scars are notable as nonthermal, low-entanglement states that exist at high energies. In this study, we used attractively interacting dysprosium gases to create scar states that are stable enough to be driven into a strongly nonlinear regime while retaining their character. We measured how the kinetic and total energies evolve after quenching the confining potential.

Numerical linked-cluster expansions for two-dimensional spin models with continuous disorder distributions.

We show that numerical linked cluster expansions (NLCEs) based on sufficiently large building blocks allow one to obtain accurate low-temperature results for the thermodynamic properties of spin lattice models with continuous disorder distributions. Specifically, we show that such results can be obtained computing the disorder averages in the NLCE clusters before calculating their weights. We provide a proof of concept using three different NLCEs based on L, square, and rectangle building blocks.

Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation.

Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group.

Eigenstate entanglement entropy in the integrable spin-1/2 XYZ model.

We study the average and the standard deviation of the entanglement entropy of highly excited eigenstates of the integrable interacting spin-1/2 XYZ chain away from and at special lines with U(1) symmetry and supersymmetry. We universally find that the average eigenstate entanglement entropy exhibits a volume-law coefficient that is smaller than that of quantum-chaotic interacting models. At the supersymmetric point, we resolve the effect that degeneracies have on the computed averages.

L-based numerical linked cluster expansion for square lattice models.

We introduce a numerical linked cluster expansion for square-lattice models whose building block is an L-shape cluster. For the spin-1/2 models studied in this work, we find that this expansion exhibits a similar or better convergence of the bare sums than that of the (larger) square-shaped clusters and can be used with resummation techniques (like the site- and bond-based expansions) to obtain results at even lower temperatures. We compare the performance of weak- and strong-embedding versions of this expansion in various spin-1/2 models and show that the strong-embedding version is preferable because of its convergence properties and lower computational cost.

Generalized Thermalization in Quantum-Chaotic Quadratic Hamiltonians.

Thermalization (generalized thermalization) in nonintegrable (integrable) quantum systems requires two ingredients: equilibration and agreement with the predictions of the Gibbs (generalized Gibbs) ensemble. We prove that observables that exhibit eigenstate thermalization in single-particle sector equilibrate in many-body sectors of quantum-chaotic quadratic models. Remarkably, the same observables do not exhibit eigenstate thermalization in many-body sectors (we establish that there are exponentially many outliers).

Average entanglement entropy of midspectrum eigenstates of quantum-chaotic interacting Hamiltonians.

To which degree the average entanglement entropy of midspectrum eigenstates of quantum-chaotic interacting Hamiltonians agrees with that of random pure states is a question that has attracted considerable attention in the recent years. While there is substantial evidence that the leading (volume-law) terms are identical, which and how subleading terms differ between them is less clear. Here we carry out state-of-the-art full exact diagonalization calculations of clean spin-1/2 XYZ and XXZ chains with integrability breaking terms to address this question in the absence and presence of U(1) symmetry, respectively.

A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury.

Background: Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia-the most common risk factor in humans-and analyze the additional effect of ventilator-induced lung injury (VILI).

Methods: Bronchoscopy-guided instillation of a multidrug-resistant Pseudomonas aeruginosa strain was performed in ten healthy pigs.

Observation of hydrodynamization and local prethermalization in 1D Bose gases.

Hydrodynamics accurately describe relativistic heavy-ion collision experiments well before local thermal equilibrium is established. This unexpectedly rapid onset of hydrodynamics-which takes place on the fastest available timescale-is called hydrodynamization. It occurs when an interacting quantum system is quenched with an energy density that is much greater than its ground-state energy density.

Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia.

Background: Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However, intravenous (IV) antibiotics often achieve suboptimal pulmonary concentrations. We therefore aimed to evaluate the effect of inhaled amikacin (AMK) plus IV meropenem (MEM) on bactericidal efficacy in a swine model of monolateral MDR P.

An open secret in porcine acute myocardial infarction models: The relevance of anaesthetic regime and breed in ischaemic outcomes.

Large animal models of acute myocardial infarction (AMI) play a crucial role in translating novel therapeutic approaches to patients as denoted by their use in the right-before-human testing platform. At present, the porcine model of AMI is used most frequently as it mimics the human condition and its anatomopathological features accurately. We want to describe to, and share with, the translational research community our experience of how different anaesthetic protocols (sevoflurane, midazolam, ketamine+xylazine+midazolam, and propofol) and pig breeds [Large White and Landrace x Large White (LLW)] can dramatically modify the outcomes of a well-established porcine model of closed-chest AMI.

Effects of Mechanical Insufflation-Exsufflation With Different Pressure Settings on Respiratory Mucus Displacement During Invasive Ventilation.

Background: Mechanical insufflation-exsufflation (MI-E) has been proposed as a potential strategy to generate high expiratory flows and simulate cough in the critically ill. However, efficacy and safety of MI-E during invasive mechanical ventilation are still to be fully elucidated. This study in intubated and mechanically ventilated pigs aimed to evaluate the effects of 8 combinations of insufflation-exsufflation pressures during MI-E on mucus displacement, respiratory flows, as well as respiratory mechanics and hemodynamics.

Statistical properties of the off-diagonal matrix elements of observables in eigenstates of integrable systems.

We study the statistical properties of the off-diagonal matrix elements of observables in the energy eigenstates of integrable quantum systems. They have been found to be dense in the spin-1/2 XXZ chain, while they are sparse in noninteracting systems. We focus on the quasimomentum occupation of hard-core bosons in one dimension and show that the distributions of the off-diagonal matrix elements are well described by generalized Gamma distributions, in both the presence and absence of translational invariance but not in the presence of localization.

Development and characterization of a new swine model of invasive pneumococcal pneumonia.

Streptococcus pneumoniae is the most common microbial cause of community-acquired pneumonia. Currently, there are no available models of severe pneumococcal pneumonia in mechanically ventilated animals to mimic clinical conditions of critically ill patients. We studied endogenous pulmonary flora in 4 healthy pigs and in an additional 10 pigs in which we intra-bronchially instilled S.

Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension.

Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the endothelial function, molecular signature, and mitochondrial profile of CTEPH-derived endothelial cells to better understand the pathophysiological mechanisms of endothelial dysfunction behind CTEPH, and to identify potential novel targets for the prevention and treatment of the disease. Isolated cells from specimens obtained at PEA (CTEPH-EC), were characterized based on morphology, phenotype, and functional analyses (in vitro and in vivo tubule formation, proliferation, apoptosis, and migration).

Generalized hydrodynamics in strongly interacting 1D Bose gases.

The dynamics of strongly interacting many-body quantum systems are notoriously complex and difficult to simulate. A recently proposed theory called generalized hydrodynamics (GHD) promises to efficiently accomplish such simulations for nearly integrable systems. We test GHD with bundles of ultracold one-dimensional (1D) Bose gases by performing large trap quenches in both the strong and intermediate coupling regimes.

Eigenstate thermalization for observables that break Hamiltonian symmetries and its counterpart in interacting integrable systems.

We study the off-diagonal matrix elements of observables that break the translational symmetry of a spin-chain Hamiltonian, and as such connect energy eigenstates from different total quasimomentum sectors. We consider quantum-chaotic and interacting integrable points of the Hamiltonian, and focus on average energies at the center of the spectrum. In the quantum-chaotic model, we find that there is eigenstate thermalization; specifically, the matrix elements are Gaussian distributed with a variance that is a smooth function of ω=E_{α}-E_{β} (E_{α} are the eigenenergies) and scales as 1/D (D is the Hilbert space dimension).

Eigenstate Entanglement Entropy in Random Quadratic Hamiltonians.

The eigenstate entanglement entropy is a powerful tool to distinguish integrable from generic quantum-chaotic models. In integrable models, the average eigenstate entanglement entropy (over all Hamiltonian eigenstates) has a volume-law coefficient that generally depends on the subsystem fraction. In contrast, it is maximal (subsystem fraction independent) in quantum-chaotic models.

Short-Term Effects of Appropriate Empirical Antimicrobial Treatment with Ceftolozane/Tazobactam in a Swine Model of Nosocomial Pneumonia.

The rising frequency of multidrug-resistant and extensively drug-resistant (MDR/XDR) pathogens is making more frequent the inappropriate empirical antimicrobial therapy (IEAT) in nosocomial pneumonia, which is associated with increased mortality. We aim to determine the short-term benefits of appropriate empirical antimicrobial treatment (AEAT) with ceftolozane/tazobactam (C/T) compared with IEAT with piperacillin/tazobactam (TZP) in MDR pneumonia. Twenty-one pigs with pneumonia caused by an XDR strain (susceptible to C/T but resistant to TZP) were ventilated for up to 72 h.

Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.

Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezolid in a porcine model of severe MRSA pneumonia.

Eigenstate Thermalization in a Locally Perturbed Integrable System.

Eigenstate thermalization is widely accepted as the mechanism behind thermalization in generic isolated quantum systems. Using the example of a single magnetic defect embedded in the integrable spin-1/2 XXZ chain, we show that locally perturbing an integrable system can give rise to eigenstate thermalization. Unique to such setups is the fact that thermodynamic and transport properties of the unperturbed integrable chain emerge in properties of the eigenstates of the perturbed (nonintegrable) one.

Effect of sildenafil on right ventricular performance in an experimental large-animal model of postcapillary pulmonary hypertension.

Right ventricle (RV) dysfunction is a main determinant of morbidity and mortality in postcapillary pulmonary hypertension (PH). However, currently there are not available therapies. Since reduced nitric oxide (NO) availability and cyclic guanylate monophosphate (cGMP) levels are central in this disease, therapies targeting the NO pathway might have a beneficial effect on RV performance.

Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo.

The modulation of voltage-gated K (Kv) channels, involved in cell proliferation, arises as a potential therapeutic approach for the prevention of intimal hyperplasia present in in-stent restenosis (ISR) and allograft vasculopathy (AV). We studied the effect of PAP-1, a selective blocker of Kv1.3 channels, on development of intimal hyperplasia in vitro and in vivo in 2 porcine models of vascular injury.

Targeting the Main Anatomopathological Features in Animal Models of Myocardial Infarction.

Cardiovascular disease is the leading cause of human mortality and disability worldwide, primarily due to myocardial infarction (MI) and the resultant heart failure. To address this, animal models of MI have been developed to better understand the pathophysiological process and to enable the discovery and development of new therapies. The most commonly used small and large mammal models of MI accurately reproduce histopathologically the four characteristic post-MI phases: cardiac cell death, inflammation, myocardial repair and remodelling.