Co-Infection and in a Patient with Systemic Lupus Erythematosus.

(TM) and (PJ) infection are opportunistic infections that typically affect individuals with compromised immune systems, such as those with HIV or immunodeficiency. However, these infections are rarely seen in patients with systemic lupus erythematosus (SLE). We present a case study of a 52-year-old woman diagnosed with SLE who developed a co-infection of TM and PJ after receiving glucocorticoids, mycophenolate mofetil (MMF), and belimumab therapy.

Can Capture CD86 Proteins of Macrophages in vitro.

Background: () is a thermally dimorphic fungus endemic to Southeast Asia that causes human systemic infection. Our earlier immunohistochemical studies revealed that the organisms were markedly labeled with the CD86 antigen in cutaneous lesions brought on by infection. However, the relationship between and the CD86 co-stimulatory molecule is still unknown.

Overexpression of CD86 enhances the ability of THP-1 macrophages to defend against Talaromyces marneffei.

Background: Macrophages are the first line of defense against Talaromyces marneffei. CD86 is a surface molecule expressed on antigen-presenting cells, such as macrophages, that provide costimulatory signals necessary for T cell activation and survival. In a prior study, it was shown that as infection progressed, CD86 expression levels in macrophages considerably declined while CD86 concentrations in the supernatant significantly increased.

Talaromyces marneffei Influences Macrophage Polarization and Sterilization Ability via the Arginine Metabolism Pathway in Vitro.

The opportunistic fungal pathogen Talaromyces marneffei, which is endemic across a narrow band of tropical Southeast Asia and southern China, is an intracellular pathogen that causes systemic and lethal infection through the mononuclear phagocyte system. The mechanisms by which T. marneffei successfully replicates and escapes the immune system remain unclear.

The Effect of Infection on CD86 Expression in THP-1 Cells.

Background: () is a destructive opportunistic dimorphic fungal which can cause lethiferous Talaromycosis, but the clearance of mainly depends on the innate immune response.

Objective: To investigate whether can inhibit the expression of CD86 in THP-1 cells after infection and discuss the potential mechanisms.

Methods: Western blot and immunoelectron microscopy were used to detect the CD86 expression on cultured on BHI medium at 37°C.

[Efficacy observation on chronic tension-type headache treated with acupuncture at galea tendon-muscle node].

Objective: To explore the better therapy for chronic tension-type headache (CTTH).

Methods: Two hundred and eighty-eight cases were randomized into a sticking needling group (150 cases) and an acupuncture group (138 cases). In the sticking needling group, the manual sticking needling technique was adopted to stimulate the galea tendon-muscle node.