In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free- Hydrazides Suggested as Potent Lipoxygenase Inhibitor.

Background: A combination of biologically active ligand and metal in one molecule may increase the activity and reduce the toxicity.

Objectives: In this study, the synthesis and characterization of platinum(IV) complexes with bioactive hydrazide ligands are discussed.

Method: Elemental analysis, conductivity measurements, and spectroscopic studies were used to elucidate the structure of complexes.

Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes.

Background: Antioxidant, anti-inflammatory, antiviral and antitumoral activities among others are essential characteristics in the development of novel therapeutic compounds. Acid hydrazides can form complexation with certain metal ions that positively enhance these biological characteristics.

Objective: Five new complexes of uranium with hydrazide ligands were synthesized at room temperature.

Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties.

The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion.

Studies on chemistry, spectroscopy and antioxidant activities of chromium(III)-hydrazide complexes.

Acid hydrazides are vital chemical entities due to their biological activities. Upon complexation with certain metal ions, their biological activities are known to be positively enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and their structural, spectroscopic and antioxidant properties to reveal their chemistry and biochemistry.

Synthesis, spectroscopic and radical scavenging studies of palladium(II)-hydrazide complexes.

In present study, a series of palladium(II) complexes with biologically active hydrazide ligands have been synthesized, characterized and screened for their antioxidant (superoxide and DPPH radical scavenging) properties. Spectral studies (FT-IR, EI-mass, (13)C and (1)H NMR spectroscopy) and physico-chemical measurements including elemental analysis, magnetic susceptibility and conductivity measurements represented square planar structure for all complexes. Substituted and unsubstituted benzohydrazides (1-4) have shown monodentate behavior forming complexes of general formula [PdL2Cl2].

Synthesis, immunomodulation and cytotoxic effects of vanadium (IV) complexes.

Vanadium is known to exhibit several bioactivities and shows potential as a pharmaceutical drug. The current studies were conducted with the goal of synthesizing a new generation of oxovanadium(IV) complexes, investigating their effects on cancer cell proliferation and their immunomodulatory properties, and predicting possible structure activity relationships. The elucidation of the structures of the synthesized complexes was achieved using elemental analysis, conductivity measurements, magnetic property measurements, and IR and electronic spectroscopies.

3-(2-Ethyl-2-phenyl-hydrazin-1-yl-idene)indolin-2-one.

In the title compound, C16H15N3O, the dihedral angle between the indole ring system (r.m.s.

3-Amino-N'-(2-oxoindolin-3-yl-idene)benzohydrazide.

The title compound, C(15)H(12)N(4)O(2), contains two substituted benzohydrazide and indole rings linked via a C=N double bond. The dihedral angle between the benzene ring and the indole ring system is 11.38 (10)°.

Studies on the redox characteristics of ferrioxamine E.

Thermodynamic parameters for the reduction of ferrioxamine E as calculated from redox potentials determined at four different temperatures were found to be DeltaH( not equal)=7.1+/-3.4 kJ mol(-1) and DeltaS( not equal)=-146 J mol(-1) K(-1).

3-Chloro-benzohydrazide.

In the title compound, C(7)H(7)ClN(2)O, the hydrazide group is inclined at a dihedral angle of 32.30 (11)° with respect to the benzene ring. The amino H atoms form inter-molecular N-H⋯O hydrogen bonds with the O atoms of two adjacent mol-ecules, resulting in 10-membered rings of graph-set motif R(2) (2)(10).

Enzyme inhibition, radical scavenging, and spectroscopic studies of vanadium(IV)-hydrazide complexes.

Spectroscopic, enzyme-inhibition, and free-radical scavenging properties of a series of hydrazide ligands and their vanadium(IV) complexes have been investigated. Analytical and spectral data indicate the presence of a dimeric unit with two oxovanadium(IV) ions (VO(2+)) coordinated with two hydrazide ligands along with two water molecules. All complexes are stable in the solid state, but exhibit varying degrees of stability in solution.

4-Hydroxy-benzohydrazide.

In the title compound, C(7)H(8)N(2)O(2), the mean planes of the benzene ring and the planar hydrazide group are inclined at 25.75 (6)° with respect to each other. The structure is stabilized by inter-molecular N-H⋯O and O-H⋯N hydrogen bonds.

4-Methoxy-benzohydrazide.

The title compound, C(8)H(10)N(2)O(2), is stabilized by three inter-molecular hydrogen bonds of the N-H⋯O and N-H⋯N types. Two intra-molecular inter-actions of the N-H⋯O and C-H⋯O types are also observed.

2-Methoxy-benzohydrazide.

The title compound, C(8)H(10)N(2)O(2), crystallizes as two independent mol-ecules linked by N-H⋯N and N-H⋯O hydrogen bonds into a linear chain running along the a axis of the monoclinic unit cell. The intra- and inter-molecular hydrogen bonds are described as a two-ring R(2) (2)(10) motif. The six-membered R(1) (1)(6) rings formed by the intra-molecular inter-actions are almost planar (r.

3-Methoxy-benzohydrazide.

The title compound, C(8)H(10)N(2)O(2), crystallizes with two independent mol-ecules in an asymmetric unit. The structure is stabilized by nine inter-molecular N-H⋯N, N-H⋯O and C-H⋯O hydrogen bonds.

4-Phenyl-semicarbazide.

The title compound, C(7)H(9)N(3)O, crystallizes with two independent mol-ecules per asymmetric unit. The structure is stabilized by four distinct inter-molecular N-H⋯O hydrogen bonds. Four intra-molecular inter-actions of the N-H⋯N and C-H⋯O types are also observed.

4-Iodo-benzohydrazide.

In the structure of the title compound, C(7)H(7)IN(2)O, the hydrazide group is inclined at 13.3 (3)° with respect to the benzene ring. The structure is stabilized by inter-molecular N-H⋯N and N-H⋯O hydrogen bonds involving the hydrazide group, resulting in six- and ten-membered rings with R(2) (2)(6) and R(2) (2)(10) graph-set notations, respectively.

Oxovanadium(IV) complexes of hydrazides: potential antifungal agents.

Oxovanadium(IV) -derived antifungals have been prepared by condensing equimolar amounts of vanadyl sulfate with hydrazides. All the synthesized ligands and their metal complexes were characterized by IR, UV-Visible and micro analytical data. These synthesized compounds were screened for their antifungal activity against Aspergillus flavus (A.