[Practitioners in Psychotherapy can Improve their Competences in Assessing Attachment in Middle Childhood: Psychometric Quality of an Attachment Screening Tool Relevant forTherapy].

Attachment narratives are increasingly used as a diagnostic tool in the therapeutic work with children in middle childhood. This, however, demands extensive procedures to ensure its adequate analysis and reliability.Thus, a new diagnostic instrument has been developed.

A chemically fueled supramolecular glue for self-healing gels.

Chemically fueled supramolecular materials offer unique properties that include spatial and temporal control and even the ability to self-heal. Indeed, a few studies have demonstrated the ability to self-heal, however, the underlying mechanisms remain unclear. Here, we designed a peptide that forms a fibrillar network upon chemical fueling.

Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.

Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic [4.3.

Long-Lasting Decrease of the Acquisition of and Gram-Negative Bacteria Producing Extended Spectrum Beta-Lactamase (ESBL) by Transient Application of Probiotics.

Previously it was shown that application of probiotics stopped the acquisition of vancomycin-resistant (VRE) by patients in an early rehabilitation ward. Once the application of probiotics ended, we examined whether acquisition of VRE reoccurred. Furthermore, we examined whether probiotics altered prevalence of vancomycin-susceptible (VSE) and Gram-negative bacteria, which produce extended spectrum beta-lactamase (ESBL).

Treatment with and Nissle is safe and associated with reduced nosocomial transmission of B vancomycin-resistant on an early rehabilitation ward in Germany: a retrospective analysis.

Purpose: According to the WHO vancomycin-resistant (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance A gene VRE is differentiated from B VRE and other types. In this retrospective analysis the results of VRE surveillance performed at a German tertiary hospital with approximately 1,200 beds between 2013 and 2017 are shown.

Dissipative assemblies that inhibit their deactivation.

Dissipative self-assembly is a process in which energy-consuming chemical reaction networks drive the assembly of molecules. Prominent examples from biology include the GTP-fueled microtubule and ATP-driven actin assembly. Pattern formation and oscillatory behavior are some of the unique properties of the emerging assemblies.

Self-selection of dissipative assemblies driven by primitive chemical reaction networks.

Life is a dissipative nonequilibrium structure that requires constant consumption of energy to sustain itself. How such an unstable state could have selected from an abiotic pool of molecules remains a mystery. Here we show that liquid phase-separation offers a mechanism for the selection of dissipative products from a library of reacting molecules.

Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.

FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven difficult, and many FKBPs and Mips still lack biologically useful ligands.

Findings from an outbreak of carbapenem-resistant Klebsiella pneumoniae emphasize the role of antibiotic treatment for cross transmission.

Purpose: In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition.

Methods: In the present study, the outbreak is described and risk factors for CKP acquisition are examined, e.

Non-equilibrium dissipative supramolecular materials with a tunable lifetime.

Many biological materials exist in non-equilibrium states driven by the irreversible consumption of high-energy molecules like ATP or GTP. These energy-dissipating structures are governed by kinetics and are thus endowed with unique properties including spatiotemporal control over their presence. Here we show man-made equivalents of materials driven by the consumption of high-energy molecules and explore their unique properties.

Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment.

A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them.