An elemental diet protects mouse salivary glands from 5-fluorouracil-induced atrophy.

An elemental diet (ED) reduces adverse effects of chemotherapy, including oral mucositis, in patients with cancer. However, the detailed mechanism(s) of the healing effects of an ED remains unclear. In the present study, the protective effects of the ED, Elental, were examined against 5-fluorouracil (5-FU)-induced oral mucositis and salivary gland atrophy in mice.

Amino Acids May Have Protective Effects on Salivary Glands of 5-FU-administered Mice.

Background/aim: This study aimed to identify the most useful components of Elental in the treatment of 5-fluorouracil (FU)-induced mucositis and salivary gland atrophy in mice.

Materials And Methods: Mice (except the control group) were intraperitoneally injected with 5-FU. The mice received saline (control group and 5-FU group), dextrin (Dextrin group), amino acids (17AA group), or Elental (Elental group).