Endometriosis - A Chameleon: Patients' Perception of Clinical Symptoms, Treatment Strategies and Their Impact on Symptoms.

Endometriosis is a chronic disease with differing clinical presentations. Treatment strategies depend mainly on clinical presentation and patient lifestyle. In women newly diagnosed with endometriosis, it is often difficult to understand the pathophysiologic origin, the potential individual impairment due to disease and the different treatment options.

Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.

The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions in its two principal germinal zones during development, the ventricular zone (VZ) and the subventricular zone (SVZ). Using mRNA sequencing, we analyzed the transcriptomes of fetal human and embryonic mouse VZ, SVZ, and cortical plate. In mouse, the transcriptome of the SVZ was more similar to that of the cortical plate than that of the VZ, whereas in human the opposite was the case, with the inner and outer SVZ being highly related to each other despite their cytoarchitectonic differences.

Neonatal freshwater drowning after birth in the bathroom.

The macroscopic and microscopic findings in neonatal freshwater drowning are demonstrated on the basis of 3 exemplary cases of birth in the bathroom after concealed pregnancy. If the newborn is expelled under water and remains there until death, the lungs cannot be ventilated with air. In case of incomplete or only temporary submersion, aeration of the lungs may develop in the immediate postpartum period.

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling.

A major cause of the cerebral cortex expansion that occurred during evolution is the increase in subventricular zone (SVZ) progenitors. We found that progenitors in the outer SVZ (OSVZ) of developing human neocortex retain features of radial glia, in contrast to rodent SVZ progenitors, which have limited proliferation potential. Although delaminating from apical adherens junctions, OSVZ progenitors maintained a basal process contacting the basal lamina, a canonical epithelial property.

[Fetal acidemia and neonatal encephalopathy].

Objective: The purpose of this study was to determine the significance of fetal acidemia for newborn encephalopathy (NEP) and for the combination of NEP and multiorgan system dysfunction (MOS). In particular the influence of acidemia will be contrasted with criteria of pregnancy and delivery.

Study Design: 248 infants delivered with cord umbilical arterial pH < 7.

[-Case report of clinical and pathophysiological similarities of Moschkowitz disease and HELLP syndrome-].

This case report describes for the first time a manifestation of thrombotic thrombocytopenic purpura (TTP, Moschcowitz's disease) during pregnancy. The characteristic neurologic symptoms of TTP were missing, while the typical clinical signs of the HELLP syndrome could be observed. Furthermore the biochemical proof of TTP was obtained by tracing ultra-large clotting factor VIII (von Willebrand factor) multimers in the patient's plasma.

[Administration of pethidine in labor with meconium contaminated amniotic fluid: effect on fetal outcome and respiratory disorders].

Objective: The aim of the study was to evaluate the effects of maternal pethidine administration on fetal outcome and incidence of neonatal respiratory distress in deliveries with meconium stained amniotic fluid (MAF).

Study Design: Between 1989 and 1992, 849 live infants had MAF. For pain relief during labor 214 women received pethidine 50-150 mg i.

[Fetal heart rate monitoring in the upright pregnant woman].

In a prospective study were performed methods for electronic supervision in 163 lying and standing patients beyond the end of pregnancy. Results of the nonstress test (NST) and standing challenge test (SCT) were correlated with late and severe variable decelerations of fetal heart rate during labor, Apgar scores at 5 minutes and pH in arterial cord blood. The correlation of NST and SCT results and the various measures of fetal and neonatal condition indicated that an individual fetus at risk cannot be identified with a high degree of accuracy.

[Correlation of progesterone and apoprotein B in pregnancy].

For the synthesis of progesterone the placenta uses cholesterol which is derived from low density lipoproteins (LDL). Apoprotein B (apo B) is the mediator for the uptake of LDL into the cell. This investigation was done to find relations between progesterone and apo B concentrations in the blood serum of pregnant women.

[Prevention of meconium aspiration].

The aim of the study was to determine the risk of meconium aspiration by perinatal and obstetric characteristics and to give directions for prophylactic management. 67 infants with meconium-stained amniotic fluid received intrapartum pharyngeal suctioning and postpartum direct laryngoscopy and suctioning of the trachea. The risk for the presence of meconium in airways is increased if meconium is visible at the vocal cords (p less than 0.

[Pregnancy with ventriculoperitoneal drainage in hydrocephalus internus].

Reported is a case of ventriculo-peritoneal shunt owing to hydrocephalus internus and partial thrombosis of V. cava. By means of the case the reasons of increased intracranial pressure and its prevention in pregnancy and delivery are discussed.

[Intrahepatic pregnancy cholestasis and fetal risk].

The influence of intrahepatic pregnancy cholestasia on fetal risk is examined. Fetal risk depends predominantly on prematurity and immanent somatic and neurologic immaturity. The rate of premature labour is 35 per cent.

[Use of small neuroleptanalgesia sub partu].

Application of 0.1 mg Fentanyl and 5 mg Droperidol iv. (obstetric neurolept-analgesia) causes an enduring pain relief.

[Osteogenesis imperfecta and pregnancy].

This paper deals with three cases of osteogenesis imperfecta and pregnancy. The significance of this disease with regard to genetic advice, pregnancy and delivery is discussed considering the classification of Sillence.

[Risk following intrauterine death of one of the fetuses in twin pregnancy].

Eleven twin pregnancies in which one of the two foetuses had died more than 24 hours before birth were evaluated for this report. Intra-uterine death of one foetus did not necessarily entail death of the other. The vitality of a newborn and the neonatal period were not affected by death of one of the twins.